Transcriptional regulation inducible nitric-oxide synthase gene

Ganster, R.W., Taylor, B.S., Shao, L., and Geller, D.A. (2001). Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-kappa B. Proc. Natl. Acad. Sci. USA 9S(15), 8638-8643. 

Nunokawa, Y., Oikawa, S., and Tanaka, S. (1996). Human inducible nitric oxide synthase gene is transcriptionally regulated by nuclear factor-kappaB dependent mechanism. Biochem. Biophys. Res. Commun. 223, 347-352. 

In addition we have shown that IL-1 also induces the expression of c-jun in both islets and RINm5F cells, and have obtained preliminary evidence for nuclear factor RB (NF-kB) activation (J. A. Corbett and M. L. McDaniel, unpublished observation). TTiese three transcriptional regulators alone or in combination are believed to participate in IL-1-induced expression of nitric oxide synthase by the islet j8 cell. Importantly, Nathan and co-workers have shown the presence of NF-kB response elements upstream of the mouse macrophage iNOS gene (Xie et cd., 1993). 

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