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Cocaine- and amphetamine-regulated transcript

Appetite-suppressing. Neuropqrtide modulators and gut hormones with anorexigenic effects are a-melanocortin-stimulating hormone (a-MSH), cocaine- and amphetamine-regulated transcript (CART), glucagon-like peptide-1 (GLP-1), leptin, insulin, oxyntomodulin, pancreatic peptide PP, peptide YY and PYY3 36, and others. [Pg.90]

CART (cocaine- and amphetamine-regulated transcript) is a hypothalamic peptide that inhibits both normal and starvation-induced feeding when injected into cerebral ventricles of rats. CART is co-localized with the anorexigenic peptide a-melanocyte-stimulating hormone in neurons of the arcuate nucleus. Secretion of CART is stimulated by leptin and CART may be an endogenous inhibitor of food intake. [Pg.328]

Cocaine- and amphetamine-regulated transcript (CART) peptides are putative neurotransmitters are found in those dopaminergic brain regions. Stimulants seem to alter CART mRNA and peptide levels [2]. [Pg.1040]

Control of feeding behavior involves peripheral peptides (insulin, ghrelin, leptin) plus several peptides in the CNS (orexins/hypocretins, CCK, galanin, MSH, neuropeptide Y, CRH, cocaine-and-amphetamine-regulated transcript (CART)) [35, 36]. Some of the same peptides are involved in reward systems crucial to drug addiction. Specific receptor blockers are being tested for many of these peptide-receptor systems, with the hope of very selective actins with minimal side effects [35], For example, there are two CCK receptor subtypes, CCK-A and... [Pg.330]

AMAN acute motor axonal neuropathy CART cocaine- and amphetamine-regulated transcript... [Pg.963]

CART, cocaine and amphetamine-regulated transcript CNS, central nervous system. [Pg.830]

Brunetti L, Orlando G, Michelotto B, Recinella L, Vacca M (2000) Cocaine- and amphetamine-regulated transcript peptide-(55-102) and thyrotropin releasing hormone inhibit hypothalamic dopamine release. Eur J Pharmacol 409 103-107. [Pg.500]

The cocaine- and amphetamine-regulated transcript receptor is involved in the action of CART as a leptin-induced, hypothalamic anorexigenic (appetite-suppressing) hormone, CNS stimulant and inducer of catecholamine release from presynaptic storage granules. [Pg.165]

Cocaine- and Amphetamine-regulated transcript (CART) receptor (CART-R)... [Pg.220]

CaMPKs I—IV, calmodulin-dependent protein kinases I-IV CART, cocaine- and amphetamine-regulated transcript CART-R, cocaine- and amphetamine-regulated transcript receptor CAT, catecholamine... [Pg.840]

Other peptides which affect feeding behaviour are found in the hypothalamus. They include the orexigenic peptides neuropeptide Y (NPY) and agouti-related protein (AgRp), and the anorexic peptides melanocyte-stimulating hormone (MSH) and cocaine- and amphetamine-regulated transcript (CART) (see below). [Pg.8]

Cocaine- and amphetamine-regulated transcript (CART) is found in the periventricular nucleus of the hypothalamus. It inhibits food intake in laboratory animals by countering the action of NPY (Lambert et al. 1998). [Pg.12]

Brennan MF. Uncomphcated starvation versus cancer cachexia. Cancer Res 1977 37 2359-2364. Broberger C. Hypothalamic cocaine- and amphetamine-regulated transcript (CART) neurons histochemical... [Pg.395]

See other pages where Cocaine- and amphetamine-regulated transcript is mentioned: [Pg.158]    [Pg.159]    [Pg.210]    [Pg.212]    [Pg.380]    [Pg.835]    [Pg.1489]    [Pg.319]    [Pg.509]    [Pg.511]    [Pg.512]    [Pg.135]    [Pg.137]    [Pg.165]    [Pg.687]    [Pg.158]    [Pg.159]    [Pg.210]    [Pg.212]    [Pg.380]    [Pg.835]    [Pg.7]    [Pg.404]    [Pg.178]    [Pg.75]    [Pg.244]    [Pg.248]   
See also in sourсe #XX -- [ Pg.248 ]



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Amphetamines (amphetamine and

And cocaine

Cocaine amphetamines

Cocaine- and amphetamine-regulated

Regulation transcription

Transcriptional regulation

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