Transcriptional Regulation Activation by Cytokines

tumor cells (Sherman et al., 1993), pancreatic islets (Kleemann et al., 1993 Yamada etai, 1993 Eizirik etai, 1993), vascular smooth muscle cells (Koide et al., 1994 Beasley and Eldridge, 1994 Sirsjo et al., 1994 Perrella et al., 1994 MacNaul and Hutchinson, 1993), platelets (Mehta et al., 1995), mesangial cells (Kunz et al., 1994), and renal tubular epithelium (Markewitz et al., 1993). The cytokine response profile of the individual cell type dictates the inciting agent. 

DNA region is implicated in this effect. Recent in vivo evidence has confirmed these in vitro findings. Homozygous IRF-1 (—/-) mice do not exhibit an iNOS response following infection with cytokines or viruses (Kamijo et al 1994). 

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