A transcriptional regulation

PMURAR a Transcriptional regulator Inhibition of cell proliferation induction of apoptosis increase in sensitivity against ATRA... 

Other approaches could use transcriptional regulators that directly bind the substrate or product of the reaction and activate the reporter gene. For instance, a mutant transcriptional activator from Pseudomonas putida, NahH, was used that can bind various benzoic acids to develop a screening/selection method to detect the action of benzaldehyde dehydrogenase [45]. A transcriptional regulator may need to be engineered to bind the desired compound before it can be used in such a manner [46]. 

Hochstrasser, M., and Varshavsky, A. (1990). In vivo degradation of a transcriptional regulator the yeast o2 repressor. Cell 61,697-708. 

Mathews, H. et al.. Activation tagging in tomato identifies a transcriptional regulator of anthocyanin biosynthesis, modification, and transport. Plant Cell, 15, 1689, 2003. 

Leroux, B. Yanofsky, M.F. Winans, S.C. Ward, J.E. Ziegler, S.E Nester, E.W. Characterization of the virA locus of Agrobacterium tumefaciens a transcriptional regulator and host range determinant. EMBO J., 6, 849-856 (1987)... 

Groisman, E., Chiao, E., Lipps, C., Heffron, F., Salmonella typhimurium phoP virulence gene is a transcriptional regulator. Proc Natl Acad Sci USA 86 (1989) 7077-7081. 

AGT I plays a key role in the adaptive response and hence, it is sometimes also referred to as Ada and it is encoded by the ada gene in E. coli. It is unusual in that it becomes inactivated as a consequence of the transfer of the alkyl group to its cysteine residues and hence it is described as a suicide enzyme. 06-AGT I has dual functions one as a repair protein and the other as a transcriptional regulator of genes involved in the repair of alkylation damage. Levels of the protein increase... 

Figure 9 Sex pheromone signaling leading to conjugative plasmid transfer in Enterococcus faecalis. Sex pheromone (cX) is encoded in the N-terminal leader moiety of lipoprotein. The leader peptide is cleaved off after the translocation of lipoprotein and further processed to generate the pheromone, which is eventually excreted. The secreted pheromone is reimported into the plasmid-donor cell and bound to TraA, which is a transcriptional regulator. Eventually, aggregation substance is induced on the donor cell surface, which leads to plasmid transfer to recipient cell.

Fig. 10.9 (a) A transcriptional regulator protein bound to a distal enhancer recruits the co-activator CBP and possibiy other co-activators, indicated by... 

A transcription-regulating protein that binds to DNA in the promoter loop. See Benoff, B., Yang, H., Lawson, C.L. et al.. Structural basis of transcription activation the CAP-alpha CTD-DNA complex. Science 297, 1562-1566, 2002 Balaeff, A., Madadevan, L., and Schulten, K., Structural basis for cooperative DNA binding by CAP and lac repressor. Structure 12, 123-132, 2004 Akaboshi, E., Dynamic profiles of DNA analysis of CAP-and LexA protein-binding regions with endonucleases, DNA Cell Biol. 24, 161-172, 2005. 

Sox4 a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may also function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. 

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