Regulation of transcription factors

Vandromme, M., Gauthier-Rouviere, C., Lamb, N., and Fernandez, A. (1996). Regulation of transcription factor localization fine-tuning of gene expression. Trends Biochem. 

Recent investigations into intracellular events have begun to define the postsynaptic events through which TCAs appear to exert their effects (Morinobu et ah, 1995). One of the observations made was down-regulation of transcription factors for early gene products such as c-Fos. C-Fos is normally produced in response to periods of stress. In research with rats, TCAs as well as other antidepressants have been shown to decrease the expression of c-Fos in areas of frontal cortex after chronic but not acute treatment. Other psychotropic medications (e.g., cocaine and haloperidol) with similar acute effects on norepinephrine/serotonin neurotransmission have not shown this same chronic effect. It has been speculated that the decreased production of c-Fos is the end product of a cascade of events stimulated by increased norepinephrine levels (Morinobu et ah, 1995). 

Schwechheimer, C. and Bevan, M., The regulation of transcription factor activity in plants. Trends Plant ScL, 3, 378, 1998. 

I am indebted in my presentation of the excellent work of Robert Grimble of the Southampton University [21-24], who studied the key role of Cys in the amino acid economy of the body under inflammatory conditions. He effectively explains the biochemistry of SAA as being linked-up with the recent findings of molecular biology on the regulation of transcription factors. Based on the proposed immunomodulatory role played by SAA, he wrote ... 

The literature abounds in studies on thiol regulation of transcription factor activation. However and more relevant to physio-pathological conditions, a great body of evidence is available on supplementing NAC in several different animal models. 

West AE, Griffith EC, Greenberg ME (2002) Regulation of transcription factors by neuronal activity. Nat Rev Neurosci 3(12) 921—931... 

Metalloporphyrins, characterized by a redox-active transitional metal coordinated to a cyclic porphyrin core ligand, mitigate oxidative/nitrosative stress in biological systems. Side-chain substitutions tune redox properties of metalloporphyrins to act as potent superoxide dismutase mimetics, peroxynitrite decomposition catalysts, and redox regulators of transcription factor function. Metalloporphyrins are efficacious in AD models [538],... 

Kang MI, Kobayashi A, Wakabayashi N, Kim SG, Yamamoto M (2004) Scaffolding of Keapl to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes. Proc Natl Acad Sci USA 101 2046-2051 Kannan S, Jaiswal AK (2006) Low and high dose UVB regulation of transcription factor NF-E2-related factor 2. Cancer Res 66 8421-8429... 

Gius D, Bolero A, Shah S, Curry HA (1999) Intracellular oxidation/reduction status in the regulation of transcription factors NE-kappaB and AP-1. Toxicol Lett 106 93-106... 

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