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Transcriptional Regulators Ligand-dependent Activators

PPAR is a nuclear receptor-transcription factor and is ligand-dependent and expressed in several tissues. It is initially involved in adipocyte differentiation and fatty acid synthesis. Fatty acid and eicosanoids bind to PPAR and regulate transcription. PPAR activation inhibits monocyte differentiation and expression of several pro-inflammatory genes such as iNOS, TNF, etc. PPAR activation inhibits tumor cell proliferation (epithelial, colon, prostate). PPAR is involved in angiogenesis. [Pg.42]

Kawada T, Kamei Y, and Sugimoto E (1996) The possibility of active form of vitamins A and Das suppressors on adipocyte development via ligand-dependent transcriptional regulators. International Journal of Obesity and Related Metabolic Disorders 20(Suppl 3),S52-7. [Pg.433]

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See also in sourсe #XX -- [ Pg.177 ]



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Activated transcription

Activators transcription

Active Ligands

Dependent Transcription

Ligand activated

Ligand-activated transcription

Ligand-activated transcriptional regulator

Ligand-dependent Activators

Regulation transcription

Transcription activation

Transcription activator Regulation

Transcriptional activation

Transcriptional activator

Transcriptional regulation

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