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Quorum-sensing

The autoinducer is a low molecular weight compound that is easily leached from the cells into the culture medium. By the propagation of bacterial cells, the concentration of the autoinducer in the medium increases. When the concentration reaches a certain threshold, the biosynthesis of bioluminescence system begins, and the bacteria become luminescent. The process is also called quorum sensing (Fuqua et al., 1994). [Pg.42]

Fuqua, W. C.,Winans, S. C.,and Greenberg, E. P. (1994). Quorum sensing in bacteria the LuxR-LuxI family of cell density-responsive transcriptional regulators./. Bacteriol. 176 269-275. [Pg.396]

A rapid synthesis of carbon-14 labeled [l-14C]levulinic acid from simple building blocks has been demonstrated by Johansen and coworkers (Scheme 6.172) [324], In all three of the synthetic steps, starting from bromo[l-14C]acetic acid, microwave heating was used to accelerate the reactions, allowing a total preparation time of less than 1 h. The labeled levulinic acid was subsequently transformed into (5Z)-4-bromo-5-(bromomethylene)-2(5H)-furanone in a bromination/oxidation sequence (not shown), a potent quorum sensing inhibitor. [Pg.218]

Annand SK and Griffiths MW. 2003. Quorum sensing and expression of virulence in Escherichia coli... [Pg.351]

Bearson BL and Bearson SM. 2008. The role of die QseC quorum-sensing sensor kinase in colonization and norepinephrine-enhanced motility of Salmonella enterica serovar Typhimurium. Microb Pathogenesis... [Pg.351]

Rasch M, Andersen JB, Nielsen KF, Flodgaard LR, Christensen H, Givskov M and Gram L. 2005. Involvement of bacterial quorum-sensing signals in spoilage of bean sprouts. Appl Environ Microbiol 71 (6) 3321—3330. [Pg.354]

Sperandio V, Torres AG and Kaper JB. 2002. Quorum sensing Escherichia coli regulators B and C (QseBC) a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli. Mol Microbiol 43(3) 809-821. [Pg.354]

Zhang K, Ou M, Wang W and Ling J. 2009. Effects of quorum sensing on cell viability in Streptococcus mutcrns biofilm formation. Biochem Biophys Res Commun 379(4) 933—938. [Pg.355]

Rasmussen TB, Manefield M, Andersen JB, Eberl L, Anthoni U, Christophersen C, Steinberg P, Kjellberg S, Givskov M (2000) How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1. Microbiology 146 3237-3244 Rosemeyer H (2004) The chemodiversity of purine as a constituent of natural products. Chem Biodiversity 1 361 101... [Pg.24]

Daniels R, Vanderleyden J, Michiels J (2004) Quorum sensing and swarming migration in bacteria. FEMS Microbiol Rev 28 261-289... [Pg.240]

Rasmussen TB, Givskov M (2006) Quorum sensing inhibitors a bargain of effects. Microbiology 152 895-904... [Pg.242]

Tait K, Joint I, Daykin M, Milton DL, Williams P, Camara M (2005) Disruption of quorum sensing in seawater abolishes attraction of zoospores of the green alga Ulva to bacterial biofilms. Environ Microbiol 7 229-240... [Pg.244]

Inhibition of Quorum Sensing as an Anti-infective Strategy. 307... [Pg.291]

Keywords Quorum sensing Cell-cell signalling N-Acylhomoserine lactones Antibacterial agents Bacterial pheromones... [Pg.291]

Fig. 5 Structures of some inhibitors of AHL-dependent quorum sensing... Fig. 5 Structures of some inhibitors of AHL-dependent quorum sensing...
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