Transcriptional Regulation of the TH Gene

The effects of hypoxia on TH promoter activity in PC 12 cells have been studied by deletion analysis and transient expression of various TH promoter- 

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HIF3a is not well known (51). HIFl, or ARNT, the aryl-hydrocarbon nuclear translocator, belongs to the class I of bHLH-PAS proteins and was first described as binding to the aryl hydrocarbon receptor (AHR), which is also a member of class II of bHLH-PAS proteins (46). 

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