Aminotransferases transcriptional regulators

On the other hand, the pathways to both aromatic amino acids, Phe (1)/Tyr (2), in vascular plants are only beginning to be clarified, and could not readily be deduced from bacterial/fungal sequence/comparisons, for example, in terms of substrate(s). Thus the key to fully understanding the pathways to these two aromatic amino acids in plants was to identify the enzymes, as well as to ultimately establish their substrate specificities/ feedback properties that is, of the actual dehydratases, dehydrogenases, and aromatic aminotransferases involved, including how transcriptional regulation is attained. 

E. coli fell into the PKS associated gene. These included an AGP, four /3-ketoacyl AGP synthases, an aminotransferase, an AGP reductase, and a ketoreductase (Figure 9). Two transcription factors (a LysR-type response regulator and a IclR-type response regulator) located adjacent to the predicted biosynthetic genes... 

In rats fed a diet adequate in vitamin Bg, the fraction of total pyridoxal phosphate found in the nuclei of liver cells was 21%, and this increased to 39% in rats fed a vitamin Bg-deflcient diet, indicating a conservation of the vitamin in the nuclear compartment during deficiency. Pyridoxal phosphate in the cell nucleus is protein bound, and this protein has an apparent molecular mass of 50 to 55 kDa. Cells grown in the presence of 5 mM pyridoxine have a decreased glucocorticoid-dependent induction of enzymes such as tyrosine aminotransferase. Vitamin Bg regulates transcriptional activation of human glucocorticoid receptors in the HeLa cells. The modulatory role in transcription is not restricted to the glucocorticoid receptor but extends to other members of the steroid hormone super family. The intracellular concentration of PLP could have a profound influence on steroid hormone-induced... 

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