Mycobacterium, tuberculosis

R = R = H) are intermediate, and gentamicin and tobramycin are most susceptible (66). Resistance to streptomycin is widespread, and its use is currently confined primarily to infections caused by Mycobacterium tuberculosis Yersiniapestis and Francisella tularensis. 

Alcohols, particularly ethanol [64-17-5] and 2-propanol [67-63-9] are important disinfectants and antiseptics. In the aUphatic series of straight-chain alcohols, the antimicrobial activity increases with increasing molecular weight up to a maximum, depending on the organism tested. For Staphylococcus aureus the maximum activity occurs using amyl alcohol [71-41-0], for Salmonella typhosa, octyl alcohol [111-87-5], CgH gO (43) ioT Mycobacterium tuberculosis... 

Eig. 1. The quasispeciftc effect ia the homologous series of o-alkyl-/)-chloropheaol derivatives agaiast A = Salmonella typhosa-, B = Staphyloccus aureus-, C = Mycobacterium tuberculosis-, D = Candidaalbicans. Pheaol coefficieat is the activity of the chemical tested compared to that of pheaol. 

Sudol uses fractions of coal tar rich in xylenols and ethylphenols. It is much more active and less corrosive than lysol, and remains more active in the presence of organic matter. The phenol coefficients of sudol against Mycobacterium tuberculosis, Staphylococcus aureus, and Pseudomonas aeruginosa are 6.3, 6, and 4, respectively. It also is slowly sporicidal (97). 

M Wilson, J DeRisi, HH Kristensen, P Imboden, S Rane, PO Brown, GK Schoolmk. Exploring drug-induced alterations m gene expression m Mycobacterium tuberculosis by microairay hybridization. Proc Natl Acad Sci USA 96 12833-12838, 1999. 

Centers for Disease Control and Prevention. Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care facilities, 1994, MMWR, vol. 43 (RR-L3), 1994, 1-132. 

The thiophene analog of chloramphenicol (255) has been synthesized,as also have been similar structures. The antibacterial activity of all was much lower than that of the natural antibiotic. The thioamide of 2-thenoic acid has been prepared in a study of potential antitubercular compounds. It did not surpass thioisonico-tinamide in antitubercular activity. The thiosemicarbazones of thio-phenealdehydes and ketones (cf. Section VII,D) show high activity against Mycobacterium tuberculosis, but are very toxic. The thiosemi-carbazone of 4-(2-thienyl)-3-buten-2-one has been reported to be capable of completely inhibiting the in vitro growth of M. tuberculosis even in relatively low concentrations. ... 

Although a humoral immune response is the primaiy protection against most viral and some bacterial diseases, protective defense against other pathogens such as HIV, Plasmodium and Mycobacterium tuberculosis requires a cytotoxic response mediated by CD8+ T-cells (CTL response). Since the introduction of the vaccination concept by Jenner almost 200 yeats ago, only few vaccines have been developed that are able to induce a CTL response. These vaccines are usually attenuated live vaccines that are accompanied by certain risks and are not readily available for most pathogens. The immense appeal of DNA vaccines can be attributed to a considerable part to the fact that they are able to induce... 

AC A8 A08.001 Signal peptidase II Drug target for Mycobacterium tuberculosis infection... 

In the late 1940s Stacey, with the able and enthusiastic assistance of Paul Kent, examined polysaccharide material from Mycobacterium tuberculosis human strain. From heat-killed cells, two stable, serologically specific polysaccharide fractions and a degraded bacterial glycogen were isolated and examined. 

Mycobacterium tuberculosis, polysaccharides from, Maurice Stacey s work. 7-8... 

Grandia, A.A., Devisser, H., Vanembden, J.D.A., Vanderzee, R., Vanderberg, W.B., Hazenberg, M.P. (1991). Natural antibodies to 65 kD mycobacterial heat shock protein in rats do not correlate with susceptibility for mycobacterium-tuberculosis induced adjuvant arthritis. Immunobiology 182, 127-134. 

Baeyer-Villiger monooxygenase (BVMOMtbs) Mycobacterium tuberculosis H37Rv 2006 [140] 2006 [140] [140,141]... 

The identification of a novel BVMO from Mycobacterium tuberculosis (BVMOMtbs) complements this toolbox, as this particular biocatalyst performs a classical kinetic resolution instead of a regiodivergent oxidation vith complete consumption of substrate [140]. Notably, this enzyme accepts only one ketone enantiomer and converts it selectively to the abnormal lactone while the antipodal substrate remains unchanged (Scheme 9.24) [141]. 

Extraction of Mycobacterium tuberculosis Aoyama B. with hot water. 

Drobniewski E.A., More P.G., Harris G. S. Differentiation of Mycobacterium tuberculosis complex and nontuberculous mycobacterial liquid cultures by using peptide nucleic acid-fluorescence in situ hybridization probes./. Clin. Microbiol. 2000 38 444-447. 

Babaogln K, Page MA, Jones VC, McNeil MR, Dong C, Naismith JH, Lee RE. Novel inhibitors of an emerging target in Mycobacterium tuberculosis, snbsti-tnted thiazolidinones as inhibitors of dTDP-rhamnose synthesis. Bioorg Med Chem Lett 2003 13 3227-30. 

D-Arabinose occurs in arabinogalactans and arabinomannans elaborated by Mycobacterium species. When this had been determined, for example, for some arabinomannans, it was found to be furanosidic and a-linked. The arabinogalactan from Mycobacterium tuberculosis,however, contains both a- and y -linked D-arabinofuranosyl residues. It also occurs in the a-form in the LPS from Pseudomonas maltophila strain NCIB 9204. l-Arabinose is a component of the LPS from the purple, sulfur bacterium Chromatium vinosum. °... 

Peterson PK, Sharp BM, Gekker G, Jackson B, Balfour HH Jr (1991) Opiates, human peripheral blood mononuclear cells, and HIV. Adv Exp Med Biol 288 171-178 Peterson PK, Gekker G, Schut R, Hu S, Balfour HH Jr, Chao CC (1993) Enhancement of HlV-1 replication by opiates and cocaine the cytokine connection. Adv Exp Med Biol 335 181-188 Peterson PK, Gekker G, Hu S, Sheng WS, Molitor TW, Chao CC (1995) Morphine stimulates phagocytosis of Mycobacterium tuberculosis by human microglial cells involvement of a G protein-coupled opiate receptor. Adv Neuroimmunol 5 299-309 Peterson PK, Molitor TW, Chao CC (1998) The opioid-cytokine connection. J Neuroimmunol 83 63-69... 

Mycobacterium tuberculosis is the causal organism of tuberculosis in humans. Allied strains cause infections in animals, e.g. bovine tuberculosis and tuberculosis in rodents. Due to the waxy nature of the cell wall this organism will resist desiccation and will survive in sputum. Tuberculosis has been largely eliminated by immunization and chemotherapy. 

Mycobacterium tuberculosis Rifampicin + isoniazid + ethambutol + pyrazinamide ... 

The advent of multidrug resistant strains of Mycobacterium tuberculosis (MDR-TB) has led to increased fears of untreatable infections by serious pathogens. Rifampicin, streptomycin and, occasionally, the quinolones are drugs used in the treatment of mycobacterial infections and resistance to those agents is as described previously. There... 

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