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Antituberculosis drugs Mycobacterium tuberculosis

Treatment problems that can arise are mainly of two types adverse reactions (collateral, toxic, or hypersusceptibility reactions), and initial or acquired resistance of Mycobacterium tuberculosis, Mycobacterium bovis, or non-tuberculous mycobacteria to one or more of the antituberculosis drugs. The latter probably only occurs when the patient has not taken the full combination or the full doses of the drugs all the time. Combination formulations are thus particularly useful. Multidrug-resistant tuberculosis, defined as resistance against at least isoniazid and rifampicin, is the most clinically relevant form of resistance to treatment worldwide. [Pg.322]

In an in vitro susceptibility study of 170 clinical isolates of Mycobacterium tuberculosis to fusidic acid, 19 isolates were resistant to at least one first-Une antituberculosis drug (21). In all, 1.8% of the isolates were resistant to fusidic acid. Fusidic acid can be a potential supplementary drug for the treatment of infections due to multidrug-resistant strains of M. tuberculosis. [Pg.1461]

Rifapentine is an antituberculosis agent that inhibits DNA-dependent RNA polymerase in susceptible strains of Mycobacterium tuberculosis. It is bactericidal for intracellular and extracellular M. tuberculosis organisms. It is indicated in the treatment of pulmonary tuberculosis in conjunction with one or more other antituberculosis drugs to which the isolate is susceptible. [Pg.621]


See other pages where Antituberculosis drugs Mycobacterium tuberculosis is mentioned: [Pg.193]    [Pg.525]    [Pg.525]    [Pg.1706]    [Pg.346]    [Pg.368]    [Pg.193]    [Pg.20]    [Pg.85]    [Pg.197]    [Pg.129]    [Pg.193]    [Pg.20]    [Pg.200]    [Pg.623]    [Pg.623]    [Pg.624]    [Pg.624]    [Pg.626]    [Pg.73]    [Pg.188]    [Pg.277]   
See also in sourсe #XX -- [ Pg.623 , Pg.624 ]




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Antituberculosis drug

Mycobacterium

Mycobacterium tuberculosis

Tuberculosis

Tuberculosis drugs

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