Mycobacterium tuberculosis chemokines

Peters W, Scott HM, Chambers HF, Flyim JL, Charo IF, Ernst JD. Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. Proc Natl Acad Sci USA 2001 98 7958-7963. 

Kasahara K, Sato I, Ogura K, Takeuchi H, Kobayashi K, Adachi M. Expression of chemokines and induction of rapid cell death in human blood neutrophils by Mycobacterium tuberculosis. J Infect Dis 1998 178 127-137. 

Lin Y, Zhang M, Bames PF. Chemokine production by a human alveolar epithelial cell line in response to Mycobacterium tuberculosis. Infect Immun 1998 66 1121-1126. 

Interaction between mycobacterium and leukocytes can also result in modulation of the receptors for ELR+ CXC chemokines. Human neutrophils down-regulate their surface expression of CXCR2 upon initial interaction with either M. tuberculosis or mycobacterial lipomannas (62), perhaps indicating an antiinflammatory counterregulatory mechanism. Similarly, peripheral blood monocytes of patients with tuberculosis have reduced expression of both CXCRl and -2 compared to uninfected patients (70). Interestingly, HIV-infected patients with tuberculosis have an even lower expression of CXCRl and -2 than non-HIV patients with tuberculosis (70). In addition, peripheral monocytes from patients with both HIV and tuberculosis infections have reduced IL-8 production in response to LPS, and IL-8-induced neutrophil degranulation is impaired (71,72). These abnormalities may contribute to the impaired host defense of patients with HIV to mycobacterial infections. 

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