Peptide-nucleic acids

Peptide Nucleic Acids (PNAs) Are Synthetic Mimics ofDNA and RNA... 

Peptide nucleic acid, a molecule with two identities 99ACR624. 

Locked nucleic acid (LNA) Peptide nucleic acid (PNA) Morpholine phosphoroamidate (MF)... 

Bentin, T. and P.E. Nielsen. Superior duplex DNA strand invasion by acridine conjugated peptide nucleic acids. J. Am. Chem. Soc. 2003, 125, 6378-6379. 

I 4 Peptide Nucleic Acid (PNA) A Pseudo-peptide with DNA-like Properties... 

The development of the aminoethylglycine polyamide (peptide) backbone oligomer with pendant nucleobases linked to the glycine nitrogen via an acetyl bridge now often referred to by PNA (peptide nucleic acid Fig. 4.1), was inspired... 

The hypothesis that our biological world built on the DNA-RNA-protein central dogma was preceded by an RNA world in which RNA molecules carried both the genetic information and executed the gene functions (through ribozyme activity) is now widely accepted [130]. However, it is also well recognized that RNA due to its vulnerability to hydrolysis - especially as a result of catalysis by divalent metal ions - would not have been able to evolve in a harsh pre-biotic environment Also the formation of RNA under presumed pre-biotic conditions is extremely inefficient It is not so far-fetched to propose that a peptide nucleic acid-like molecule may have been able to function as a form of pre-biotic genetic material since it... 

Nielsen P.E. Peptide nucleic acid. A molecule with two identities. Acc. Chem. Res. 1999, 32 624-630. 

WiTTUNG P., Nielsen P. E., Buchardt O., Egholm M., Norden B. DNA-like double helix formed by peptide nucleic acid. Nature 1994, 368 561-563. 

Nielsen P.E., Egholm M., Berg R. H., Buchardt O. Peptide nucleic acids (PNA) oligonucleotide analogs with a polyamide backbone. In Antisense Research and Applications. Crooke S.T., Le-BLBu B. (Eds). CRC Press, Boca Raton,... 

Griffith M.C., Risen L.M., Greig M.J., Lesnik E.A., Sprankle K.G., Griffey R.H., Kiely J.S., Eeier S.M. Single and bis peptide nucleic acids as triplex-ing agents binding and stoichiometry. 

Larsen H.J., Nielsen P.E. Transcription-mediated binding of peptide nucleic acid (PNA) to double-stranded DNA sequence-specific suicide transcription. Nucleic Acids Res. 1996 24 458-463. 

Bentin T., Nielsen P. E. Enhanced peptide nucleic acid binding to supercoiled DNA possible implications for DNA breathing dynamics. Biochemistry 1996 35 8863-8869. 

Kaihatsu K., Braasch D.A., Cansizo-GLU A., Corey D.R. Enhanced strand invasion by peptide nucleic acid-peptide conjugates. Biochemistry 2002 41 11118-11125. 

Bentin T, Nielsen P.E. Combined tri-plex/duplex invasion of double-stranded DNA by Tail-Clamp peptide nucleic acids (PNA). (Submitted)... 

HanveyJ.C., Peeeer N.J., Bisi J.E., Thomson S.A., Cadilla R., Josey J.A., Ricca D.J., Hassman C.F., Bonham M.A. Antisense and antigene properties of peptide nucleic acids. Science 1992 258 1481-1485. 

Gambacorti-Passerini C., Mologni L, Bertazzoli C., le Coutre P., Marchesi E., Grignani F., Nielsen P.E. In vitro transcription and translation inhibition by anti-promyelocytic leukemia (PML)/re-tinoic acid receptor-alpha and anti-PML peptide nucleic acid. Blood 1996 88 1411-1417. 

Norton J.C., Piatyszek M.A., Wright W. E., Shay J.W., Corey D.R. Inhibition of human telomerase activity by peptide nucleic acids. Nature Biotechnol. 1996 14 615-618. 

Hamilton S. E., Simmons C.G., Kathir-iya I.S., Corey D.R. Cellular delivery of peptide nucleic acids and inhibition of human telomerase. Chem. Biol. 1999 6 343-351. 

Boffa L.C., Scarf S., Marian M.R., Dai40nte G, Allfrey V.G., Benatti U., Morris O. L. Dihydrotestosterone as a selective cellular/nuclear localization vector for anti-gene peptide nucleic acid in prostatic carcinoma cells. Cancer Res. 2000 60 2258-2262. 

Sun L., Fuselier J.A., Murphy W.A., Coy D.H. Antisense peptide nucleic acids conjugated to somatostatin analogs and targeted at the n-myc oncogene display enhanced cytotoxity to human neuroblastoma 1M.R.32 cells expressing somatostatin receptors. Peptides 2002 23 1557-1565. 

Mologni L., Marches E., Nielsen P.E., Gai4BACOrti-Passerini C. Inhibition of promyelocytic leukemia (PML)/retinoic acid receptor-alpha and PML expression in acute promyelocytic leukemia cells by anti-PML peptide nucleic acid. Cancer Res. 2001 61 5468-5473. 

Hoen P.A. C., Prince P., Van der Bilt E., Valentijn A. R., Meeuwenoord N.J., Princen H., Bijsterbosch M.K., van der Marel G.A., van Boom J.H., van BerkelT.J.C. Design of a targeted peptide nucleic acid prodrug to inhibit hepatic human microsomal triglyceride transfer protein expression in hepato-cytes. Bioconjug. Chem. 2002 13 295-302. 

Adlerz L., Soomets U., Holmlund L., Viiriaid S., Langel U., Iverfeldt K. Down-regulation of amyloid precursor protein by peptide nucleic acid oligomer in cultured rat primary neurons and astrocytes. Neurosci. Lett. 2003 336 55-59. 

Mery J., Brugidou Rabie A. A peptide nucleic acid (PNA) is more rapidly internalized in cultured neurons when coupled to a retro-inverso delivery peptide. The antisense activity depresses the target mRNA and protein in magnocellu-lar oxytocin neurons. Nucleic Acids Res. 

Shammas M.A., Simmons C.G., Corey D.R., Reis R.J.S. Telomerase inhibition by peptide nucleic acids reverses immortality of transformed human cells. Oncogene 1999 18 6191-6200... 

Karras J.G., Maier M.A., Lu T, Watt A., Manoharan M. Peptide nucleic acids are potent modulators of endogenous pre-mRNA splicing of the murine inter-leukin-5 receptor-alpha chain. Biochemistry 2001 40 7853-7859. 

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