Mycobacterium tuberculosis. See

Fig. 6. Distribution of the most common folds in selected bacterial, archaeal, and eukaryotic proteomes. The vertical axis shows the fraction of all predicted folds in the respective proteome. Fold name abbreviations FAD/NAD, FAD/NAD(P)-binding Rossman-like domains TIM, TIM-barrel domains SAM-MTR, S-adenosylmethionine-dependent methyltransferases PK, serine-threonine protein kinases PP-Loop, ATP pyrophosphatases. mge, Mycoplasma genitalium rpr, Rickettsiaprowazekii hh x, Borrelia burgdorferi ctr, Chlamydia trachomatis hpy, Helicobacter pylori tma, Thermotoga maritima ssp, Synechocystis sp. mtu, Mycobacterium tuberculosis eco, Escherichia coli mja, Methanococcus jannaschii pho, Pyrococcus horikoshii see, Saccharomyces cerevisiae, cel, Caenorhabditis elegans.

The Ee " chelating properties of exochelin MN (17) were investigated in detail (pK values, chelation constants, redox equilibria, etc.) (87). In one publication (128) siderophores from Mycobacterium tuberculosis otherwise referred to as carboxymycobactins (see below Sect. 2.8) were also named exochelins. 

In 2003, Sunthitikawinsakul et al. described the anti-mycobacterial activity of various 3-methylcarbazole derivatives, including 3-formylcarbazole (3), methyl carbazole-3-carboxylate (4) (see Scheme 2.2), clausine K (clauszoline-J) (51) (see Scheme 2.11), and 7-methoxymukonal (68) (see Scheme 2.14) against Mycobacterium tuberculosis H37Ra. Except for clausine K (clauszoline-J) (51), all of these alkaloids also showed anti-fungal activity against Candida albicans (442). In 2005, Eranzblau et al. reported the in vitro anti-TB activity of various carbazole derivatives such as 3-formylcarbazole (3), methyl carbazole-3-carboxylate (4) (see Scheme 2.2), lansine... 

Carbazole-l,4-quinones, the key intermediates of this approach, can be even more effidently prepared by the palladium(II)-catalyzed oxidative cydization (see below. Scheme 15.17). In a screening for anti-TB active carbazoles, 3-methoxy-2-methyl-carbazole-l,4-quinone showed significant inhibition of Mycobacterium tuberculosis strain H37RV, with an MIC90 value 2.2 p.g/mL (9 p,M) [40]. Thus, carbazoles may be developed as anti-TB drug candidates by structural modifications. 

Mucoproteins. See Proteins, muco-. Mycobacterium tuberculosis, polysaccharides of, 3, 311-336... 

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