Mycobacterium tuberculosis antigenicity

Schoel, B., Guile, H., and Kauftnatm, S.H. 1992, Heterogeneity of the repertoire of T cells of tuberculosis patients and healthy contacts to Mycobacterium tuberculosis antigens separated by high-resolution techniques. Infection Immunity 60 1717-1720. 

Matulis G, Juni P, Villiger PM, et al. Detection of latent tuberculosis in immu-nosupptessed patients with autoimmune diseases performance of a mycobacterium tuberculosis antigen specific IFN-gamma assay. Ann Rheum Dis 2008 67 84—90. 

Del Prete, G., De, C.M., Mastromauro, C., Biagiotti, R., Macchia, D., Falagiani, P., Ricci, M. and Romagnani, S. (1991) Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara cams expand human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. Journal of Clinical Investigation 88, 346-350. 

BahkYY, Kim SA, Kim JS etal (2004) Antigens secreted from Mycobacterium tuberculosis identification by proteomics approach and test for diagnostic marker. Proteomics 4 3299-3307... 

In order to provide access here to information about other microbial polysaccharides, there follows a short review of reviews. The Chemical Nature of Bacterial Antigens is a source of information on the earlier work, and this was followed by two reviews - in the present Series in one of these, the bacterial homopolysaccharides were discussed and some of the more complex products were mentioned. A wide review of mucopolysaccharides and mucoproteins included references to many bacterial polysaccharides, and, subsequently, an account of the specific polysaccharides of the Gram-positive Pneumococcus, and of dextrans, levans, and products of Gram-negative forms appeared. There followed a comprehensive review of pneumococcal polysaccharides, and an account restricted to products of Mycobacterium tuberculosis appeared in 1948. A broad coverage was provided in 1950, in this case the products of pathogenic species being dealt with more particularly this work encompassed the basis of the more... 

Garsia, R. J., Hellqvist, L., Booth, R. J., Radford. A. ]., Britton, W. ]., Astbury, L., Trent, R. J., and Basten, A. (1989). Homology of the 70-kilodalton antigens from Mycobacterium leprae and Mycobacterium boins with the Mycobacterium tuberculosis 71-kilodalton... 

Boyden and Sorkin, in an excellent review on antigens of Mycobacterium tuberculosis, think that it is still not completely clear whether antibodies are formed against any of the lipid molecules, as distinct from polysaccharide or protein components of lipidic complexes. ... 

Veeneman, G H, van Leeuwen, S H, Zuurmond, H, van Boom, J H, Synthesis of carbohydrate-antigenic structures of Mycobacterium tuberculosis using iodonium ion promoted glycosidation approach, J. Carbohydr. Chem., 9, 783-796, 1990. 

In contrast to contact hypersensitivity, tuberculin-type hypersensitivity reactions are primarily dermal and result from intradermal injections into the skin. In people that have had tuberculosis or have been exposed to the bacterium through infection or BCG immunization, a cell-mediated immune response to the bacterium develops. When small amounts of tuberculin (a complex mixture of antigenic material derived from Mycobacterium tuberculosis) are subsequently injected into the skin, a localized T cell-dependent inflammatory response develops in the dermis. Within 24-72 h of injection, individuals with prior exposure to the bacterium display a raised, red, indurated area on the skin at the injection site. The lack of a response suggests no prior exposure to the bacterium. 

Roberts, A.D., Sonnenberg, M.G., Ordway, D.J., Fumey, S.K., Brennan, PJ, Belisle, J.T., and Orme, I.M. 1995, Characteristics of protective immunity engendered by vaccination of mice with purified culture filtrate protein antigens of Mycobacterium tuberculosis. 

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