Mycobacterium tuberculosis purified protein derivative

Purified protein derivative (PPD) Material used in the tuberculin skin test, the most common test for exposure to Mycobacterium tuberculosis. 

Del Prete, G., De, C.M., Mastromauro, C., Biagiotti, R., Macchia, D., Falagiani, P., Ricci, M. and Romagnani, S. (1991) Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara cams expand human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. Journal of Clinical Investigation 88, 346-350. 

Note The PPD is a purified protein derivative of Mycobacterium tuberculosis that is injected subcutaneously into the volar surface of the forearm to stimulate a hypersensitivity reaction. If, within 24 to 48 hours there is an area of induration greater than 10 mm in diameter, it is a positive PPD test and indicates that the patient had been exposed to and infected with Mycobacterium tuberculosis.] The patient s test was positive. Due to his homeless status, it is likely that he came in contact with TB-infected individuals. 

Radiation therapy (RT) is a successful therapeutic approach in cancer treatment. Besides its cytotoxic effects on tumour cells, RT also has immunomodulatory effects. The ability of peripheral blood T cells to proliferate to PPD (purified protein derivative of Mycobacterium tuberculosis) was impaired in... 

Tuberculin skin test An immunological test for tuberculosis in which a purified protein derivative from the Mycobacterium tuberculosis is injected subcutaneously, resulting in an induration if there was previous exposure to the bacterium. 

Wiley, C. A., Masliah, E., Morey, M., Lemere, C., Deteresa, R., Grafe, M., Hansen, L., and Terry, R. (1991). Neocortical damage during HIV infection. Ann. Neurol. 29, 651-657. Wilkinson, P. C., and Newman, I. (1992). Identification of IL-8 as a locomotor attractant for activated human lymphocytes in mononuclear cell cultures with anti-CD3 or purified protein derivative of Mycobacterium tuberculosis. J. Immunol. 149, 2689-2694. 

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