Adjuvant-induced arthritis

AIA, adjuvant-induced arthritis CFA, complete Freund s adjuvant CIA, collagen-induced arthritis DTH, delayed-type hypersensitivity LPS, lipopolysaccharide. 

Szekanecz Z, Halloran MM, Volin MV, et al. Temporal expression of inflammatory cytokines and chemokines in rat adjuvant-induced arthritis. Arthritis Rheum 2000 43(6) 1266-1277. 

Shahrara S, Amin MA, Woods JM, Haines GK, Koch AE. Chemokine receptor expression and in vivo signaling pathways in the joints of rats with adjuvant-induced arthritis. Arthritis Rheum 2003 48(12) 3568-3583. 

Haas CS, Martinez RJ, Attia N, Haines GK 3rd, Campbell PL, Koch AE. Chemokine receptor expression in rat adjuvant-induced arthritis. Arthritis Rheum 2005 52( 12) 3718-3730. 

Barnes DA, Tse J, Kaufhold M, et al. Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis model. J Clin Invest 1998 101(12) 2910-2919. 

Halloran MM, Woods JM, Stricter RM, et al. The role of an epithelial neutrophilactivating peptide-78-like protein in rat adjuvant-induced arthritis. J Immunol 1999 162(12) 7492-7500. 

Lubahn, C.L. et al., The importance of timing of adrenergic drug delivery in relation to the induction and onset of adjuvant-induced arthritis, Brain Behav. Immun., 18, 563, 2004. 

Butler, S. H., Weil-Fugazza, J., Godefroy, F., Besson, J. M. Reduction of arthritis and pain behaviour following chronic administration of amitryptiline or imipramine in rats with adjuvant-induced arthritis, Pain 1985, 23, 159-175. 

Fishman P, Bar-Yehuda S, Madi L, Rath-Wolfson L, Ochaion A, Cohen S, Baharav E (2006) The PI3K-NF-kappaB signal transduction pathway is involved in mediating the anti-inflammatory effect of IB-MECA in adjuvant-induced arthritis. Arthritis Res Ther 8(1) R33 Fossetta J, Jackson J, Deno G, Fan X, Du XK, Bober L, Soude-Bermejo A, de Bouteiller O, Caux C, Lunn C, Lundell D, Palmer RK (2003) Pharmacological analysis of calcium responses mediated by the human A3 adenosine receptor in monocyte-derived dendritic cells and recombinant cells. Mol Pharmacol 63(2) 342-350... 

Ochaion A, Bar-Yehuda S, Cohen S, Amital H, Jacobson KA, Joshi BV, Gao ZG, Barer F, Patoka R, Del Valle L, Perez-Liz G, Fishman P (2008) The A3 adenosine receptor agonist CF502 inhibits the PI3K, PKB/Akt and NF-kappaB signaling pathway in synoviocytes from rheumatoid arthritis patients and in adjuvant-induced arthritis rats. Biochem Pharmacol... 

Fishman P (2008) Clinical evidence for utilization of the A3 adenosine receptor as a target to treat rheumatoid arthritis data from a phase II clinical trial. J Rheumatol 35(1 ) 41—48 Sizova L (2008) Approaches to the treatment of early rheumatoid arthritis with disease-modifying antirheumatic drugs. Br J Clin Pharmacol 66(2) 173-178 Spargo LD, Cleland LG, Cockshell MP, Mayrhofer G (2006) Recruitment and proliferation of CD4+ T cells in synovium following adoptive transfer of adjuvant-induced arthritis. Int Immunol 18(6) 897-910... 

Lee JY, Kang SS, KimJH, et al. Inhibitory effect of whole bee venom in adjuvant-induced arthritis. In Vivo. 2005 19 801-805. 

Easter Island (Rapa Nui) first discovered and characterized by Sehgal in 1975 (38), Initially identified as an antifungal agent, the compound was subsequently found to posses potent immunosuppressive activities, initially demonstrated through its ability to prevent adjuvant-induced arthritis and experimental allergic encephalomyelitis in rodent models. As a potent immunosuppressive agent, sirolimus has been developed and marketed by Wyeth Pharmaceuticals for the prevention of renal transplant rejection (Rapamune ) (39). 

Male Sprague Dawley or spontaneously hypertensive stroke prone Wistar or Lewis rats with adjuvant induced arthritis weighing 150-300 g or New Zealand rabbits with arteriosclerosis induced by cholesterol feeding for 3 months are used. The animals receive the test compound by oral, intravenous, intraperitoneal, or subcutaneous administration. Control animals are treated with vehicle alone. Prior to thrombus induction, the animals are pretreated by s.c. injection of... 

Since ancient times, the roots of Scutellaria baicalensis have been used to treat allergic and inflammatory diseases in China and Japan. We reported the isolation from these roots of three new compounds, i.e., 2 S), 2, 5,6, 7-tetetahydroxy flavanone[25], 2 R), 3(i )-2, 3,5,6, 7-pentahydroxyflavanone and 2, 5,5, 7-tetrahydroxy-6, 8-dimethoxy-flavone, as antibacterial or anti-lipid peroxidation substances [26, 27], as well as six flavonoids, i.e., baicalein, bailcalin, oroxylin A, wogonin, skullcapflavone II, etc. Furthermore, we found that baicalein and baicalin "Fig. (47)" suppressed the development of secondary lesions in adjuvant-induced arthritis in rats "Fig. (48)". 

To clarify the inhibitory effects of these flavonoids from Scutellariae radix on adjuvant-induced arthritis, we further examined the effects of these flavonoids on leukotriene synthesis and adhesion molecular expression in neutrophils and vein endothelial cells. Baicalein inhibited the biosynthesis of LTs B4 and C4 in human leukocytes most strongly... 

Fig. (48). Effects of baicalein and baicalin isolated from the roots of Scutellaria baicalensis on adjuvant-induced arthritis in rats.

Intramuscular administration of gold SAuPEt3 sodium thiomalate appeared to be less effective In suppressing the lesions of adjuvant induced arthritis in rats, produced relatively higher levels of gold in the sera and kidneys and marked toxicity when compared with an... 

Calza L, Pozza M, Zanni M, Manzini CU, Manzini E, Hokfelt T (1998) Peptide plasticity in primary sensory neurons and spinal cord during adjuvant-induced arthritis in the rat an immunocytochemical and in situ hybridization study. Neuroscience 82 575-589... 

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