Mycobacterium tuberculosis, occurrence

Mycobacteria are also killed in vitro, as expected from an antibiotic sharing the properties of the rifamycin family [24], In a study by Soro et al. [25], the MIC of rifaximin was determined for five Mycobacterium tuberculosis isolates from patients with tuberculosis. MIC concentrations were studied at 6, 20, 90 and 270 pg/ml, respectively. No resistant organisms were found. Growing M. tuberculosis in the presence of varying doses of rifaximin did not induce the occurrence of rifampicin-resistant strains [25]. In addition to this, experimental tubercular infection in the guinea pig was found not to be affected by an oral treatment course with rifaximin, therefore confirming the lack of absorption of the molecule after oral administration [26],... 

DC026 Gottshall, R. Y., E. H. Lucas, A. Lickfeldt, and ]. M. Roberts. The occurrence of antibacterial substances active against Mycobacterium tuberculosis in seed plants. J Clin Invest 1949 28 920-923. 

It is only comparatively recently that D-arabinose has been found to be a constituent of natural products in contrast to the frequent occurrence of its enantiomorph. Units of D-arabofuranose have been shown to form part of the molecules of the polysaccharides isolated from Mycobacterium tuberculosis (human strain),28 being identified as methyl 3,5-dimethyl-D-arabofuranoside in the products of hydrolysis, after methylation, of the somatic polysaccharide, and as the above glycoside and the methyl trimethyl-D-arabofuranoside in the lipid-bound fraction. 2-Methyl-D-arabinose has been synthesized. 

I. Pastuszak and M. Szymona (1980). Occurrence of a large molecular size from polyphosphate-glucose phosphotransferase in extracts of Mycobacterium tuberculosis F Ra. Acta Microbiol. Pol., 29, 49-56. 

Glynn JR, Whiteley J, Bifani PJ, Kremer K, van Soolingen D 2002 Worldwide occurrence of Beijing/W strains of Mycobacterium tuberculosis a systematic review. Emerg Infect Dis 8 843-849... 

Gottshall, R., et al. "The Occurrence of Antibacterial Substances Active Mycobacterium tuberculosis in... 

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