Feed supplementation

Urea is largely used as a fertilizer (ISy ), and as a non-protein feed supplement for sheep and cattle. The most important chemical use, which however accounts for only a small part of urea production, is in the manufacture of urea-formaldehyde resins. U is also used in the manufacture of adhesives, pharmaceuticals, dyes and various other materials. U.S. production 1981 7 0 megatonnes urea resins 1983 6 megatonnes. 

Feedstuff Feed supplements Feely-Beavers procedure Feen-a-Mint Fe4[Fe(CN)6]3xH20 FEFO... 

Fertilization of ponds to increase productivity is the next level of intensity with respect to fish culture, followed by provision of supplemental feeds. Supplemental feeds are those that provide some additional nutrition but caimot be depended upon to supply all the required nutrients. Provision of complete feeds, those that do provide all of the nutrients required by the fish, translates to another increase in intensity. Associated with one or more of the stages described might be the appHcation of techniques that lead to the maintenance of good water quaUty. Examples are continuous water exchange, mechanical aeration, and the use of various chemicals used to adjust such factors as pH, alkalinity, and hardness. 

Commercially, urea is produced by the direct dehydration of ammonium carbamate, NH2COONH4, at elevated temperature and pressure. Ammonium carbamate is obtained by direct reaction of ammonia and carbon dioxide. The two reactions are usually carried out simultaneously in a high pressure reactor. Recendy, urea has been used commercially as a catde-feed supplement (see Feeds and feed additives). Other important appHcations are the manufacture of resins (see Amino resins and plastics), glues, solvents, and some medicinals. Urea is classified as a nontoxic compound. 

Urea is also used as feed supplement for mminants, where it assists in the utilization of protein. Urea is one of the raw materials for urea—formaldehyde resins. Urea (with ammonia) pyrolyzes at high temperature and pressure to form melamine plastics (see also Cyanamides). Urea is used in the preparation of lysine, an amino acid widely used in poultry feed (see Amino acids Feeds and feed additives, petfoods). It also is used in some pesticides. 

Addition of Mercaptans. One of the largest uses of acrolein is the production of 3-methylmercaptopropionaldehyde [3268-49-3] which is an intermediate in the synthesis of Dj.-methionine [59-51-8] an important chicken feed supplement. 

Mineral Feed. Mineral feed supplements for domestic animals and fowl usually contain a pure form of pulverized limestone. In fact, some state laws require the supplement to be at least 35% available calcium. Other sources of calcium are bone meal and dicalcium phosphate. Use as mineral feed has been a steadily growing market for limestone. The material is ground to 90% minus 0.15 mm (100 mesh) or 80% minus 0.9074 mm (200 mesh), is low in silica, and has strict tolerances on arsenic and fluorine (see Feeds and feed additives). 

Hard-burned magnesias may be used in a variety of appHcations such as ceramics (qv), animal feed supplements, acid neutralization, wastewater treatment, leather (qv) tanning, magnesium phosphate cements, magnesium compound manufacturing, fertilizer, or as a raw material for fused magnesia. A patented process has introduced this material as a cation adsorbent for metals removal in wastewater treatment (132). 

Future Uses. The most recent uses for methanol can be found in the agricultural sector. Test studies are being carried out where methanol is sprayed directly onto crops to improve plant growth. Methanol can be used as a carbon source for the production of single-cell protein (SCP) for use as an animal feed supplement. The process has been commercially demonstrated by ICl at their BiUingham, U.K., faciUty. However, the production of SCP is not commercially practical at this time, in comparison to more conventional protein sources. 

Wet Process. Over 90% of the phosphoric acid produced, both in the United States and worldwide, is wet-process phosphoric acid used almost exclusively for agricultural appHcation as both fertilizers and animal feed supplements. Although constituting a small proportion of the total wet-acid production, a significant amount of phosphoric acid for food and technical appHcations is made by purification of wet-process acid. 

Uses. The principal use of monosodium phosphate is as a water-soluble soHd acid and pH buffer, primarily in acid-type cleaners. The double salt, NaH2P04 H PO, referred to as hemisodium orthophosphate or sodium hemiphosphate, is often generated in situ from monosodium phosphate and phosphoric acid in these types of formulations. Mixtures of mono- and disodium phosphates are used in textile processing, food manufacture, and other industries to control pH at 4—9. Monosodium phosphate is also used in boiler-water treatment, as a precipitant for polyvalent metal ions, and as an animal-feed supplement. 

An estimation of the amount of amino acid production and the production methods are shown ia Table 11. About 340,000 t/yr of L-glutamic acid, principally as its monosodium salt, are manufactured ia the world, about 85% ia the Asian area. The demand for DL-methionine and L-lysiae as feed supplements varies considerably depending on such factors as the soybean harvest ia the United States and the anchovy catch ia Pern. Because of the actions of D-amiao acid oxidase and i.-amino acid transamiaase ia the animal body (156), the D-form of methionine is as equally nutritive as the L-form, so that DL-methionine which is iaexpensively produced by chemical synthesis is primarily used as a feed supplement. In the United States the methionine hydroxy analogue is partially used ia place of methionine. The consumption of L-lysiae has iacreased ia recent years. The world consumption tripled from 35,000 t ia 1982 to 100,000 t ia 1987 (214). Current world consumption of L-tryptophan and i.-threonine are several tens to hundreds of tons. The demand for L-phenylalanine as the raw material for the synthesis of aspartame has been increasing markedly. 

Veterinary Applications. Another use for antibiotics is for veterinary appHcations and for animal feed supplements to promote growth in Hvestock (see Feeds and feed additives). Feed antibiotics used in the United States far surpass all other agricultural appHcations in terms of kilogram quantities used and approach quantities used in human medicines (25). In 1980 the USA feed antibiotic usage was estimated to be between five and six million kg. The U.S. Council of Agricultural Science and Technology estimates that feed additives save the U.S. consumer approximately 3500 million per year in meat prices, and antibiotic use accounts for most of this. 

Methylene-5,5-disahcyhc acid is produced by heating two parts sahcyhc acid with 1—1.5 parts of 30—40 wt % formaldehyde in the presence of an acid catalyst (33). The resulting product is a mixture of isomers, primarily the 5,5 -isomer and small amounts of low molecular weight polymers. It is used as an intermediate in the production of bacitracin methylenedisahcylate, which is used in a feed supplement to promote growth and as a medicament in swine, feedlot catde, as well as chickens, turkeys, pheasants, and quail. 

Solvent Extraction. Extraction processes, used for separating one substance from another, are commonly employed in the pharmaceutical and food processing industries. Oilseed extraction is the most widely used extraction process on the basis of tons processed. Extraction-grade hexane is the solvent used to extract soybeans, cottonseed, com, peanuts, and other oilseeds to produce edible oils and meal used for animal feed supplements. Tight specifications require a narrow distillation range to minimize solvent losses as well as an extremely low benzene content. The specification also has a composition requirement, which is very unusual for a hydrocarbon, where the different components of the solvent must be present within certain ranges (see Exthaction). 

The chemistry of organic sulfur compounds is very rich and organosulfur compounds are incorporated into many molecules. Thiols, or mercaptans as they were originally called, are essential as feedstocks in the manufacture of many types of mbber (qv) and plastics (qv). They are utilized as intermediates in agricultural chemicals, pharmaceuticals (qv), ia flavors and fragrances, and as animal feed supplements. Many reviews have been undertaken on the chemistry of the thiols, regarding both their preparation and their reactions (1 7). 

To obtain optimal performance of farm animals, foHc acid supplementation is required (86) and as is the case with most of the vitamins, the majority of worldwide consumption is as feed supplements. The foHc acid requirement for chickens and pigs is about 0.2—0.5 mg of foHc acid/kg diet and 0.3 mg/kg diet, respectively. Increased amounts, 0.5—1.0 mg/kg feed for chickens and 0.5—2.0 mg/kg for swiae, are recommended under commercial production conditions (87). The degree of intestinal foHc acid synthesis and the utilization by the animal dictates the foHc acid requirements for monogastric species. Also, the self-synthesis of folaciais dependent on dietary composition (88). 

Riboflavin is widely used in the pharmaceutical, food-enrichment, and feed-supplement industries. Riboflavin USP is adininistered orally in tablets or by injection as an aqueous solution, which may contain nicotinamide or other solubilizers. As a supplement to animal feeds, riboflavin is usually added at concentrations of 2—8 mg/kg, depending on the species and age of the animal (see Feeds AND FEED ADDITIVES). 

The most widely available yeast biomass is a by-product of the brewing industry, where the multiplication of yeast during brewing results in a surplus of ceUs. Eor every barrel (117 L) of beer brewed, 0.2—0.3 kg of yeast soHds may be recovered. In the U.S., a substantial fraction is recovered and made available about 40 x 10 kg of brewers yeast aimually. The yeast is recovered from beer by centrifuging and dried on roUer dmms or spray dryers and sold as animal feed or a pet-food supplement. It can be debittered by alkaline extraction to remove the bitter hop residues, and is then sold mainly by the health-food industry. It is available as tablets, powder, or flakes and is often fortified with additional vitamins. Distillers yeast caimot be readily separated from the fermented mash and the mixture is sold as an animal feed supplement. 

Nutrition. Zinc is essential to the proper functioning of plants and animals and, as zinc sulfate and oxide, it is used as a feed supplement (49—51) (see Mineral nutrients Feedsand feed additives). Most crops use less than a kilogram of zinc per 1000 m per year, so that zinc salts added at 1.3—4.5 kg/ha gradually build up the zinc reserve (52). Animals, including humans, store relatively Htde available zinc and, thus, require a constant supply in the diet. For instance, beef cattle require 10—30 mg/kg dry feed, dairy cattle 40 mg/kg, and breeding hens 65 mg/kg. Zinc from plants is considered less available to monogastric aminals than zinc from animal protein. 

Amine-containing cellulose esters, eg, the acetate A/A/-diethylaminoacetate (36) and propionate morpholinobutyrate (35), are of interest because of their unique solubiHty in dilute acid. Such esters are prepared by the addition of the appropriate amine to the cellulose acrylate crotonate esters or by replacement of the chlorine on cellulose acrylate chloroacetate esters with amines. This type of ester has been suggested for use in controlled release, mmen-protected feed supplements for mminants (36,37). 

A primary use for iodine is as a catalyst in the production of acetic acid (qv) (39). Iodine is converted to compounds used in mbber, stabilizers, animal feed supplements, colorants, pharmaceuticals, sanitary products, and photographic products. 

The mixture of D and L optical forms of this hydroxy analogue of methionine is converted to the calcium salt which is used in animal feed supplements. Cyanohydrins react with ammonium carbonate to form hydantoins (2), which yield amino acids upon hydrolysis. Commercial DL-methionine [59-57-8] is produced by hydrolysis of the hydantoin of 3-meth5ithiopropionaldehyde [3268-49-3]. 

World production of I2 in 1992 approached 15 000 tonnes, the dominant producers being Japan 41%, Chile 40%, USA 10% and the former Soviet Union 9%. Crude iodine is packed in double polythene-lined fibre drums of 10-50-kg capacity. Resublimed iodine is transported in lined fibre drums (11.3 kg) or in bottles containing 0.11, 0.45 or 2.26 kg. The price of I2 has traditionally fluctuated wildly. Thus, because of acute over-supply in 1990 the price for I2 peaked at 22/kg in 1988, falling to 12/kg in 1990 and 9.50/kg in 1992. Unlike CI2 and Br2, iodine has no predominant commercial outlet. About 50% is incorporated into a wide variety of organic compounds and about 15% each is accounted for as resublimed iodine, KI, and other inorganics. The end uses include catalysts for synthetic rubber manufacture, animal- and fowl-feed supplements. 

Production costs for biodiesel from soybean oil exceeds 2.00 per gal ( 0.53 per 1), compared to 0.55 to 0.65 per gal ( 0.15 to 0.17 per 1) for conventional diesel. The main cost in biodiesel is in the raw material. It takes about 7.7 lb (3.5 kg) of soybean oil valued at about 0.25 per lb (0.36 per kg) to make 1 gal (3.81) of biodiesel. Waste oils, valued at 1 per gal ( 3.79 per 1) or less, have the potential to provide low feedstock cost. However, much waste oil" is currently collected, reprocessed as yellow and white greases, and used for industrial purposes and as an animal feed supplement. Production of biodiesel... 

During cheese making, the coagulated milk or curd is used to make cheese while the supernatant whey is a waste product rich in salts, proteins, and lactose. Whey concentration and desalting by UF produce a retentate product that can be used as an animal feed supplement or food additive. The MMV process (Maubois et al., French Patent 2,052,121) involves concentrating the milk by UF after centrifugation to remove the cream and before coagulation to improve yields and reduce disposal costs. 

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