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Receptor interactions

Bongrand P 1999 Ligand-receptor interactions Rep. Prog. Phys. 62 921... [Pg.1728]

The information contained in the chemical stmcture of a given ligand is without value unless decoded and executed by the appropriate receptor. The pharmacologic analysis of dmg—receptor interactions is based on the understanding of how the dmg is recognized by the receptor, how the dmg—receptor complex forms, and how the dmg—receptor complex initiates its biological action (12). [Pg.268]

In the early twentieth century, the law of mass action was appHed to the basic pathway of dmg—receptor interaction. Assuming that response, R, is proportional to the concentration of the dmg—receptor complex, ITT, and that maximum response, occurs when all receptors are occupied (2,6,10),... [Pg.275]

Direct quantitation of receptor concentrations and dmg—receptor interactions is possible by a variety of techniques, including fluorescence, nmr, and radioligand binding. The last is particularly versatile and has been appHed both to sophisticated receptor quantitation and to dmg screening and discovery protocols (50,51). The use of high specific activity, frequendy pH]- or p lj-labeled, dmgs bound to cmde or purified cellular materials, to whole cells, or to tissue shces, permits the determination not only of dmg—receptor saturation curves, but also of the receptor number, dmg affinity, and association and dissociation kinetics either direcdy or by competition. Complete theoretical and experimental details are available (50,51). [Pg.276]

These cascades serve as operational amplifiers of the initial ligand—receptor interaction. In each step of the process, amplification by several powers of 10 may occur so that an original signal maybe multiphed several millionfold (63). [Pg.278]

Fig. 10. The receptor—G-protein sequence. An activated receptor interacts with the trimeric GDP-ligated receptor to cause an interchange of GDP by GTP and dissociation into the activated Ga—GTP (left) and G y (right) subunits. These then interact with a variety of effectors. The purpose of the activated... Fig. 10. The receptor—G-protein sequence. An activated receptor interacts with the trimeric GDP-ligated receptor to cause an interchange of GDP by GTP and dissociation into the activated Ga—GTP (left) and G y (right) subunits. These then interact with a variety of effectors. The purpose of the activated...
Receptor Regulation and Defects. Specific recognition and the initiation of response are the accepted attributes of the dmg—receptor interaction. However, target cells can alter on both short- and long-term time scales their sensitivity to dmgs. Such regulation, achieved by altering the... [Pg.281]

T. Kenakin, Pharmacological Analysis of Drug Receptor Interaction, 2nd ed.. Raven, New York, 1993 D. Oksenberg and co-workers. Nature, 360, 161 (1992). [Pg.284]

II. RELATIONSHIPS BETWEEN EXPERIMENTAL AND THEORETICAL APPROACHES TO STUDYING DRUG-RECEPTOR INTERACTIONS... [Pg.352]

Figure 1 A flow chart of experimental information about drug-receptor interaction. The objects of experimental and theoretical investigation are boxed, and the experimental information is circled. Figure 1 A flow chart of experimental information about drug-receptor interaction. The objects of experimental and theoretical investigation are boxed, and the experimental information is circled.
The interaction between ligands and their receptors is clearly a dynamic process. Once the static model of ligand-receptor interaction has been obtained, the stability of ligand-receptor complexes should be evaluated by means of molecular dynamics simulations [18]. [Pg.353]

Figure 2 A flow chart of theoretical modeling drug-receptor interaction and relation to experiment. The objects of theoretical investigation are m rectangles, and the experimental information IS m the ovals. Figure 2 A flow chart of theoretical modeling drug-receptor interaction and relation to experiment. The objects of theoretical investigation are m rectangles, and the experimental information IS m the ovals.
TL Tembe, JA McCammon. Ligand-receptor interactions. Comput Chem 8 281-283, 1984. [Pg.366]

Figure 13.22 Hormone-receptor interactions involving the domain-domain linker region in the receptor, (a) Interactions between the growth hormone (red) and the growth hormone receptor (blue) linker region. Glu 127 of the receptor forms a salt bridge to Arg 167 in the hormone, (b) The same interaction area in the growth hormone (red)-prolactin receptor (green) complex. The displacement of the linker region due to differences in the domain orientations have brought Asp 124 in the prolactin receptor into contact with Arg 167 of the hormone. (Adapted from W. Somers et al.. Nature 372 478-481, 1994.)... Figure 13.22 Hormone-receptor interactions involving the domain-domain linker region in the receptor, (a) Interactions between the growth hormone (red) and the growth hormone receptor (blue) linker region. Glu 127 of the receptor forms a salt bridge to Arg 167 in the hormone, (b) The same interaction area in the growth hormone (red)-prolactin receptor (green) complex. The displacement of the linker region due to differences in the domain orientations have brought Asp 124 in the prolactin receptor into contact with Arg 167 of the hormone. (Adapted from W. Somers et al.. Nature 372 478-481, 1994.)...
The hypothetical enantiophore queries are constructed from the CSP receptor interaction sites as listed above. They are defined in terms of geometric objects (points, lines, planes, centroids, normal vectors) and constraints (distances, angles, dihedral angles, exclusion sphere) which are directly inferred from projected CSP receptor-site points. For instance, the enantiophore in Fig. 4-7 contains three point attachments obtained by ... [Pg.107]

Figure 9.17 Imagine that a left hand interacts with a chiral object, much as a biological receptor interacts with a chiral molecule, (a) One enantiomer fits into the hand perfectly green thumb, red palm, and gray pinkie finger, with the blue substituent exposed. (b The other enantiomer, however, can t fit into the hand. When the green thumb and gray pinkie finger interact appropriately, the palm holds a blue substituent rather than a red one, with the red substituent exposed. Figure 9.17 Imagine that a left hand interacts with a chiral object, much as a biological receptor interacts with a chiral molecule, (a) One enantiomer fits into the hand perfectly green thumb, red palm, and gray pinkie finger, with the blue substituent exposed. (b The other enantiomer, however, can t fit into the hand. When the green thumb and gray pinkie finger interact appropriately, the palm holds a blue substituent rather than a red one, with the red substituent exposed.
FIGURE 1.5 Schematic diagram of response production by an agonist. An initial stimulus is produced at the receptor as a result of agonist-receptor interaction. This stimulus is processed by the stimulus-response apparatus of the cell into observable cellular response. [Pg.9]


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See also in sourсe #XX -- [ Pg.468 ]

See also in sourсe #XX -- [ Pg.8 ]




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Agonist-receptor interactions

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Binding, drug-receptor interactions based

Biochemical effects interaction with specific protein receptors

Biological receptors interactions

Biosensors ligand-receptor interactions

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CANCER METASTASIS Ligand-receptor interaction

CD44 Receptor Interactions

Cell surface receptor interactions

Cell surface receptor interactions cadherins

Characterization of the Receptor-Ligand Interaction

Chemical recognition mechanisms drug-receptor interactions

Chemokine receptors interactions with

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Diug-Receptor Interaction

Dopamine-receptor agonist interactions

Drug Interactions with Targets or Receptors

Drug delivery receptor interaction

Drug receptor interaction

Drug receptor-interaction irreversible

Drug receptor-interaction mechanisms

Drug-receptor electrostatic interactions

Drug-receptor interactions cooperative binding

Drug-receptor interactions enthalpy/entropy compensation

Drug-receptor interactions entropy

Drug-receptor interactions free energy

Drug-receptor interactions functional group contributions

Drug-receptor interactions hydrogen bonds

Drug-receptor interactions hydrophobic

Drug-receptor interactions inductive

Drug-receptor interactions lead compounds

Drug-receptor interactions principles

Drug-receptor interactions stereochemistry

Drug-receptor interactions, forces

Drug-receptor interactions, hydrogen

Duloxetine receptor interactions

Enantiomers drug-receptor interactions

Endocannabinoids interaction with cannabinoid receptors

Energy ligand-receptor interaction

Epidermal growth factor receptors interacting proteins

Estrogen receptor estradiol interactions with

Experimental Quantification of Drug-Receptor Binding Interactions

Functional groups drug-receptor interactions

G protein-coupled receptors interacting proteins

G-protein-coupled receptor interacting

GABAa receptor interacting factor

GRID interaction with receptor

Geometry in hormone-receptor interactions

Geometry ligand-receptor interactions

Glucocorticoid receptor-interacting protein

Hemoglobin (ligand:receptor interaction

High ligand-receptor interactions

Histamine receptor antagonists) interactions

Hormone receptor interaction

Hydrophilic interactions receptor binding

Hydrophobic interactions receptor binding

Hydroxyl group drug-receptor interactions

Hydroxylation ligand-receptor interactions

Inorganic anion receptors electrostatic interactions

Interaction between the ligand and receptor

Interaction mechanisms receptor structure

Interaction of Organic Compounds with Melanocortin Receptor Subtypes

Interaction receptor-protein

Interactions of Polyammonium Compounds with Isolated Acetylcholine Receptors

Interactions, protein receptor-ligand

Intracellular receptors drug interactions

Ionic bonds, drug receptor interactions

Ionotropic glutamate receptors interactions

Libraries receptor-ligand interactions

Ligand critical interaction with receptor

Ligand properties receptor interactions

Ligand-receptor interaction kinetics

Ligand-receptor interaction, cellular

Ligand-receptor interaction, cellular communication

Ligand-receptor interaction-induced

Ligand-receptor interaction-induced functional effects

Ligand-receptor interactions

Ligand-receptor interactions affinity

Ligand-receptor interactions analysis

Ligand-receptor interactions cellular responses

Ligand-receptor interactions complex

Ligand-receptor interactions molecular modeling

Ligand-receptor interactions molecules

Ligand-receptor interactions stereoselectivity

Ligand-receptor interactions, computational

Ligand-receptor interactions, computational approach

Ligand-receptor interactions, specific

Ligand-receptor interactions, specific sites

Ligands interaction with receptors

Lysosomes, receptor interactions with

Metabotropic glutamate receptors interactions

Methyl group drug-receptor interactions

Mineralocorticoid receptor interactions

Molecular Interactions and Binding Modes of CCR5 Receptor Antagonists

Molecular drug-receptor interaction

Molecular ligand-receptor interaction

Morphine receptor interactions

Neostigmine receptor interaction

Nervous system transmitter-receptor interaction

Neurotransmitter interactions with receptors

Neurotransmitters receptor interactions

Nogo receptor-interacting protein

Novel nuclear receptor-interacting

Nuclear receptor-coactivator interaction

Nuclear receptor-cofactor interaction

Odorant interaction, receptor site

Opiate receptor interactions

Opioid interaction with K-receptors

Opioid peptide-receptor interactions

Opioid-chemokine receptor interaction

Opioid-chemokine receptor interaction desensitization

Opioid-chemokine receptor interaction function

Opioid-chemokine receptor interaction receptors

Other interactions of NMDA receptors

P-Opioid receptor interaction with

Partial agonists benzodiazepine receptor interactions with

Peroxisome proliferator activated receptor interaction with genes

Pharmacodynamics drug-receptor interactions

Progesterone interactions with steroid receptors

Protein receptor interactions, binding

Proteochemometric Modeling of Chimeric MC Receptors Interacting with MSH Peptides

Publication receptor-interaction, model

Radioligands ligand-receptor interactions

Raloxifene interaction with estrogen receptors

Receptor and substrate interactions

Receptor interacting protein

Receptor interaction descriptors

Receptor interaction domains

Receptor interactions directly

Receptor interactions with

Receptor interactions with peptide hormones

Receptor interactions, determination

Receptor interactions, determination mechanism

Receptor-G protein interactions and

Receptor-Genome Interaction

Receptor-drug interactions bond types

Receptor-drug interactions conformational change

Receptor-drug interactions rate theory

Receptor-effector complex interactions

Receptor-guanine nucleotide interactions

Receptor-guest interactions

Receptor-ligand binding interactions

Receptor-ligand binding interactions equilibrium thermodynamics

Receptor-ligand interaction screening

Receptor-ligand interactions defining

Receptor-ligand interactions, affinity capillary electrophoresis

Receptor-mediated genomic interactions

Receptor-peptide interactions

Receptor-specific interaction

Receptor-virus interactions

Receptor-xenobiotic interactions

Receptors drug-receptor interactions

Receptors interaction with drugs

Receptors interactions based

Receptors, endocannabinoid conformation interaction

Retinoid receptors ligand-receptor interaction

Scoring Drug-Receptor Interactions

Significance of chemical bonding in drug-receptor interactions

Single ligand-receptor interaction

Small molecule-enzyme receptor interaction

Specificity of the Hormone-Receptor Interaction

Stereospecificity, drug-receptor interactions

Steric hindrance drug-receptor interactions

Steroid receptor-chromatin interactions

Steroid-receptor interaction

Steroid-receptor interaction chemical nature

Structure-activity relationships drug-receptor interactions

Substrate-receptor interactions

Synthetic peptide receptors noncovalent interactions

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TRAF6-Receptor Interactions Distinct Specificity

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