Steroid-receptor interaction

Pratt WB, Toft DO. (1997) Steroid receptor interactions with heat shock protein and immu-nophilin chaperones. Endocr Rev. 18, 306-360. 

Most recent studies of steroid receptor interactions with nuclear sites have focused on DNA sequences called hormone response elements adjacent to the promoter of... 

Vitamin D, along with parathyroid hormone and calcitonin, plays a primary role in calcium and phosphorus homeostasis in the body. Intensive research efforts over the past several years have elucidated a role for vitamin D in many other physiological processes as well. The biological actions of this seco-steroid are mediated primarily through the action of its polar metabolite, 1,25-dihydroxy vitamin D3 (l,25(OH)2D3). There is emerging evidence that l,25(OH)2D3 has many more target tissues than those involved in its classical role in the control of mineral metabolism. In addition, some of the actions of l,25(OH)2D3 may be mediated by mechanisms other than the classical steroid-receptor interaction. In this chapter we will provide a brief overview of the multiple actions of vitamin D3 and the pleiotropic mechanisms by which these actions are accomplished. 

Pratt WB, Toft DO. Steroid receptor interactions with heat shock... 

The first chapter deals with metabolic factors affecting the biological activities of androgens. In the second chapter the structure-activity theories are reviewed. A new approach to the structure-activity relationship is offered in Chapter 3. The effects of structural and stereochemical changes on biological activities are extensively analyzed in this chapter. A new theory of steroid-receptor interaction concludes this chapter. 

Excellent accounts of the biological effects and clinical application of anabolic steroids, by Kriiskemper [5], and of the pharmacology of anabolic steroids, by Overbeek [50], are available. It is the aim of this book to examine the chemical structure-biological activity relationship of androgens and anabolic agents. A new theory of steroid-receptor interaction is also advanced, based on a new approach to the chemical structure-biological activity relationship. 

In all previous hypotheses for the mechanism of action of hormones, the main consideration has been restricted to the question whether the a- or the j8-face of the steroid is involved in the steroid-receptor interaction. These theories are evaluated on the basis of changes in hormonal activities brought about by structural modifications. Since obviously the search is for compounds with high activity, most of the theories are derived from results brought about by optimal structural modifications. 

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