Binding interactions, drug receptor

Agonists are dru that bind with a receptor to produce a therapeutic response Dru that bind only partially to the receptor will most probably have some, although slight, therapeutic response Figure 1-3 identifies the different drug-receptor interactions. Partial agonists are dm that have some drug receptor fit and produce a response but inhibit other responses. 

For a detailed description of spectral map analysis (SMA), the reader is referred to Section 31.3.5. The method has been designed specifically for the study of drug-receptor interactions [37,44]. The interpretation of the resulting spectral map is different from that of the usual principal components biplot. The former is symmetric with respect to rows and columns, while the latter is not. In particular, the spectral map displays interactions between compounds and receptors. It shows which compounds are most specific for which receptors (or tests) and vice versa. This property will be illustrated by means of an analysis of data reporting on the binding affinities of various opioid analgesics to various opioid receptors [45,46]. In contrast with the previous approach, this application is not based on extra-thermodynamic properties, but is derived entirely from biological activity spectra. 

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