Metabotropic glutamate receptor interaction

For family C receptors, the importance of and structural basis for interaction with intracellular adaptor or scaffolding proteins have been characterized in great detail, just as the issue of dimer formation is rather clear for these receptors. The main family of adaptor proteins, which ensures the cellular targeting and correct signaling function for the metabotropic glutamate receptors, appear... 

Sorensen, S. D., Macek, T. A., Cai, Z Saugstad, J. A., and Conn, P. J. (2002) Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function. Mol. Pharmacol. 61,1303-1312. 

Romano, C., Miller, J. K., Hyrc, K., et al. (2001) Covalent and noncovalent interactions mediate metabotropic glutamate receptor mGlu5 dimerization. Mol. Pharmacol. 59, 46-53. 

Molecular Neuropharmacology Strategies and Methods is intended to bridge the gap between molecular biology and advanced chemistry. In addition, it attempts to include information about x-ray crystallographic analyses whenever available. This book discusses interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein-coupled receptors. 

Aronica E, Dell Albani P, Condorelli DF et al (1993) Mechanisms underlying developmental changes in the expression of metabotropic glutamate receptors in cultured cerebellar granule cells homologous desensitization and interactive effects involving N-methyl-D-aspartate receptors. Mol Pharmacol 44 981-9... 

Doherty, J., and Dingledine, R. (2003). Functional interactions between cannabinoid and metabotropic glutamate receptors in the central nervous system. Cun. Opin. Pharmacol. 3, 46-53. 

El Far O, Airas J, Wischmeyer E, Nehring RB, Karschin A, Betz H. Interaction of the C-terminal tail region of the metabotropic glutamate receptor 7 with the protein kinase C substrate PICK1. Eur J Neurosci 2000 12 4215-4221. 

The issue of dimerization of type C (glutamate receptor class) is clearly set. Type C GPCRs form dimers by covalent linkage of disulfide bond at their extracellular N-terminal domains (e.g. metabotropic glutamate receptor) or by strong non-covalent, intermolecular interactions (e.g. two y-aminobutyric acid, GABA, receptor subtypes). But is dimerization state also required for their function ... 

Darrah JM, Stefani MR, Moghaddam B. 2008. Interaction of N-methyl-D-aspartate and group 5 metabotropic glutamate receptors on behavioral flexibility using a novel operant set-shift paradigm. Behav Pharmacol 19 225-234. 

Mao L, Wang JQ. 2002. Interactions between ionotropic and metabotropic glutamate receptors regulate cAMP response element-binding protein phosphorylation in cultured striatal neurons. Neuroscience 115 395-402. 

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