Drug Receptor Studies

II. RELATIONSHIPS BETWEEN EXPERIMENTAL AND THEORETICAL APPROACHES TO STUDYING DRUG-RECEPTOR INTERACTIONS... 

Jenkinson, DH (1996) Classical approaches to the study of drug-receptor interactions. In Textbook of Receptor Pharmacology (Eds Foreman, JC and Johansen, T), CRC Press, Boca Raton, FL, pp. 159-185. 

Strange, PG (1996) Dopamine receptors studies on structure and function. Adv. Drug Res. 28 ... 

For a detailed description of spectral map analysis (SMA), the reader is referred to Section 31.3.5. The method has been designed specifically for the study of drug-receptor interactions [37,44]. The interpretation of the resulting spectral map is different from that of the usual principal components biplot. The former is symmetric with respect to rows and columns, while the latter is not. In particular, the spectral map displays interactions between compounds and receptors. It shows which compounds are most specific for which receptors (or tests) and vice versa. This property will be illustrated by means of an analysis of data reporting on the binding affinities of various opioid analgesics to various opioid receptors [45,46]. In contrast with the previous approach, this application is not based on extra-thermodynamic properties, but is derived entirely from biological activity spectra. 

Classical Approaches to the Study of Drug-Receptor Interactions... 

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