Receptor-Genome Interaction

Harmar AJ (2001) Family-B G-protein-coupled receptors. Genome Biol 2 3013.1-3013.10 Hata Y, Butz S, Stidhof TC (1996) CASK a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins. J Neurosci 16 2488-94... 

Receptor-mediated genomic interactions 3.2.1. l,25(OH)2D3 receptor characteristics... 

Some ligands do not interact principally with cell surface receptors, but diffuse into cells and bind to intracellular receptors in the cytoplasm. For example, ligand binding to cytoplasmic steroid receptors initiates a process that is not well understood but that involves the movement of steroid-bound receptor into the cell nucleus, where the receptor molecule interacts with genomic material, resulting in alterations in gene expression and protein synthesis. 

Zang X, Loke P, Kim J, Wojnoonski K, Kusdra L, Allison JP. A genetic library screen for signaling proteins that interact with phosphorylated T cell costimulatory receptors. Genomics 2006 88 841-845. 

PTKs can be subdivided into two large families, receptor tyrosine kinases (RTKs) and non-RTKs. The human genome encodes for a total of 90 tyrosine kinases of which 32 are nonreceptor PTKs that can be placed in 10 subfamilies (Fig. 1). All nonreceptor PTKs share a common kinase domain and usually contain several additional domains that mediate interactions with protein-binding partners, membrane lipids, or DNA (Table 1). These interactions may affect cellular localization and the activation status of the kinase or attract substrate proteins for phosphorylation reactions. 

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