Drug receptor-interaction mechanisms

Analytical models of the heart are a reality. They are based on detailed descriptions of cardiac tissue architecture and anatomy, including the coronary vasculature. In sihco cardiac tissues possess realistic passive mechanical properties, and both electrical and mechanical activity can be simulated with high accuracy. Descriptions of key components of cellular metabolism have been introduced, as have models of drug-receptor interactions. [Pg.143]

Weinstein, H., R. Osman, and J. P. Green. 1979. The Molecular Basis of Structure-Activity Relationships Quantum Chemical Recognition Mechanisms in Drug-Receptor Interactions. In Computer-Assisted Drug Design. E. C. Olson and R. E. Christofferson, eds. American Chemical Society, Washington, D.C. [Pg.83]

Drug-receptor interactions Dose-response relationships Molecular modeLs of receptors and signal transduction mechanisms Biotr an s fo r m ati on Ph ar macokine t ios Ph armacody namics... [Pg.28]

Introduced by Corwin Hansch in the early 1960s, Hansch analysis considers both the physicochemical aspects of drug distribution from the point of application to the point of effect and the drug-receptor interaction. In a given group of drugs that have analogous structures and act by the same mechanism, three parameters seem to play a major role ... [Pg.141]

Mechanism of action studies including drug receptor interactions and specific enzyme inhibitions. [Pg.83]

Gilli P, Gilli G, Borea PA, Varani K, Scatturin A, Dalpiaz A (2005) Binding thermodynamics as a tool to investigate the mechanisms of drug-receptor interactions thermodynamics of cytoplasmic steroid/nuclear receptors in comparison with membrane receptors. 1 Med Chem... [Pg.47]

Mechanism Drug-receptor interaction Drug-receptor interaction Through antigen-antibody reaction specific antibody formed in response to first dose of antigen... [Pg.116]

It is generally accepted that a drug initiates a chain of events which eventually leads to a specific biological effect but which does not involve the drug after it triggers the mechanism through a drug-receptor interaction. For example, sucrose tastes sweet, but the role of sucrose molecules is to stimulate the taste buds, and they do not participate in the process of sensory conduction as such. [Pg.12]

The Molecular Basis of Structure-Activity Relationships Quantum Chemical Recognition Mechanisms in Drug-Receptor Interactions... [Pg.160]