Apolipoproteins, functions receptor interactions

Apo E, a quantitatively minor apolipoprotein, is a 34-kd glycoprotein constituent of plasma triglyceride-rich lipoproteins and of HDL. The functional role of Apo E is most likely that of interaction with the remnant receptor in the liver [26]. Apo E is polymorphic, having three major isofonns separated by isoelectric focusing (Apo E2, E3, and E4). Each of the three polymorphic forms of Apo E is coded by a separate allele the alleles being inherited in a codominant fashion at a single genetic locus. 

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