Cooperativity drug receptor interactions

PEPER K., DREYER F. and MOlLER K., Analysis of cooperativity of drug-receptor interaction by quantitative iontophoresis at frog motor end plate. Cold Spring Harbor Symp. Quant. Biol. 40, 187-192, 1975. 

Ben-Baruch G, Schreiber G, Sokolovsky M (1982) Cooperativity pattern in the interaction of the antiestrogen drug clomiphene with the muscarinic receptors. Mol Pharmacol 21 287-293... 

Linked-function mechanisms for cooperative binding interaction of metabolites and/or drugs, based on the presence of two or more different conformational states of the protein or receptor. See Adair Equation Cooperative Ligand Binding Hemoglobin Hill Equation Plot Koshland-Nemethy-Filmer Model Monod-Wyman-Changeux Model Negative Cooperativity Positive Cooperativity... 

Schmid DA, Depta JP, LuthI M, PIchler WJ Transfection of drug-specific T-cell receptors Into hybridoma cells tools to monitor drug Interaction with T-cell receptors and evaluate cross-reactivity to related compounds. Mol Pharmacol 2006 70 356-65. Dustin ML, Cooper JA The Immunological synapse and the actin cytoskeleton molecular hardware forT cell signaling. Nat Immunol 2000 1 23-9. 

A cooperative interaction between imidazoline receptors and a 2-adrenoceptors seems to account for the marked and rapid hypotensive effect caused by hybrid drugs, such as clonidine. 

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