Receptor-drug interactions rate theory

In direct opposition to the occupation theory, the rate theory assumes that an occupied receptor is actually an eliminated one. Obviously, when studying only the equilibrium state, no evidence can be found corroborating or disproving either of these two concepts. Only the reaction course at the start of the drug-receptor interaction might solve the problem as to whether in a certain case the occupation or rate theory is more correct. Figure 14 shows the overshoot and the fade postulated by the rate theory. 

The quantitative approach to drug-receptor interaction clearly has its basis in relationships shown by Michaelis and Menten. Clark applied these ideas to drug-receptor combination Ariens distinguished between affinity and intrinsic activity using the occupation variant of the receptor theory. Paton elaborated the rate concept in receptor theory Schild found special approaches useful... 

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