Significance of chemical bonding in drug-receptor interactions

6 Significance of chemical bonding in drug-receptor interactions 

Drug -F Receptor Drug-Receptor Complex Altered Function 

Dissociated carboxylic acid group on a receptor site 

Formation of hydrophobic bonds between nonpolar hydrocarbon groups on the drug and those in the receptor site is also common. Although these bonds are not very specific, the interactions take place to exclude water molecules. Repulsive forces that decrease the stability of the drug-receptor interaction include repulsion of like charges and steric hindrance. 

Clayden, J., Greeves, N., Warren, S. and Wothers, P. Organic Chemistry, Oxford University Press, Oxford, 2001. 

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