Glucocorticoid receptor-interacting protein

Xia, J. and Kemper, B. (2005) Structural determinants of constitutive androstane receptor required for its glucocorticoid receptor interacting protein-l-mediated nuclear accumulation. The Journal of Biological Chemistry, 280, 7285—7293. 

Min, G., Kemper, J. K., and Kemper, B. (2002) Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivo. J. Biol. Chem. 277, 26356-26363. 

Widen, C., Gustafsson, J. A., and Wikstrom, A. C. (2003). Cytosolic glucocorticoid receptor interaction with nuclear factor-kappa B proteins in rat liver cells. Biochem J 373, 211-220. 

The activated glucocorticoid receptor inhibits the transcription factor T-bet by direct protein-protein interaction. 

Whereas it is conceivable that a CRH/vasopressin hyperdrive contributes to behavioral, emotional, and hormonal symptoms of mood disorders, the question remains which mechanisms mediate this hyperactivity of CRH and vasopressin-secreting neurons. The gene expression of both neuropeptides is suppressed by ligand-activated glucocorticoid receptors. The efficiency of this negative feedback action of circulating corticosteroids depends on the number of corticosteroid receptors, their affinity, and the degree of interaction with other factors (e.g., heat shock protein) involved in the transcription machinery. 

The interaction of glucocorticoid receptors with GREs or other transcription factors is facilitated or inhibited by several families of proteins called steroid receptor coregulators, divided into coactivators and corepressors. The coregulators do this by serving as bridges between the receptors and other nuclear proteins and by expressing enzymatic activities such as histone acetylase or deacetylase, which alter the... 

Kino T et al The GTP-binding (G) protein interacts with the activated glucocorticoid receptor and suppresses its transcriptional activity in the nucleus. J Cell Biol 2005 20 885. 

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