TRAF6-Receptor Interactions Distinct Specificity

In contrast to the shared receptor binding specificity among TRAFl, 2, 3, and 5, TRAF6 has a unique receptor interaction specificity that is not shared by other members of the TRAF family. In addition, TRAF6 is the only TRAF family member that also participates in the signal transduction of the IL-IR/TLR superfamily by its specificity for IRAKs. 

Apo-TRAF6 I TRAF6 in complex I TRAF2 in complex I TRAF6-bindlng peptide I TRAF2-binding peptide 

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