Plasticizers dibutyl sebacate

Fig. 7. Schematic diagram of digoxin antibody sensing electrode (a) PVC membrane containing digoxin-carrier conjugate (b) inner filling solution, 0.01 M KCI (c) plasticizer, dibutyl sebacate (d) digoxin antibodies. (From 152, with permission)...

A variety of additives are incorporated into the dispersions as surfactants (Tween 80, sodium lauryl sulfate, polyoxyethylene nonyl phenyl ether, cetyl alcohol, and Pluronic F-68), plasticizers (dibutyl sebacate, oleic acid, and Myvacet 9-40), pigments, antiadherents (fumed silica), anticoagulant (Myvacet 9-40), preservatives (sorbic acid), and stabilizers (ammonia). ... 

PVB resins are also compatible with a limited number of plasticizers and resins. Plasticizers (qv) improve processibility, lower T, and increase flexibihty and resiUency over a broad temperature range. Usehil plasticizers include dibutyl and butyl benzyl phthalates, tricresyl and 2-ethylhexyl diphenyl phosphates, butyl ricinoleate, dibutyl sebacate, dihexyl adipate, triethylene glycol di-2-ethylbutyrate, tetraethylene glycol diheptanoate, castor oil, and others (64-73). 

Diesters. Many of the diester derivatives are commercially important. The diesters are important plasticizers, polymer intermediates, and synthetic lubricants. The diesters of azelaic and sebacic acids are useflil as monomeric plasticizing agents these perform weU at low temperatures and are less water-soluble and less volatile than are diesters of adipic acid. Azelate diesters, eg, di- -hexyl, di(2-ethylhexyl), and dibutyl, are useflil plasticizing agents for poly(vinyl chloride), synthetic mbbers, nitroceUulose, and other derivatized ceUuloses (104). The di-hexyl azelates and dibutyl sebacate are sanctioned by the U.S. Food and Dmg Administration for use in poly(vinyl chloride) films and in other plastics with direct contact to food. The di(2-ethylhexyl) and dibenzyl sebacates are also valuable plasticizers. Monomeric plasticizers have also been prepared from other diacids, notably dodecanedioic, brassyflc, and 8-eth5lhexadecanedioic (88), but these have not enjoyed the commercialization of the sebacic and azelaic diesters. 

Plasticizers are used in the polymer industry to improve flexibility, workability, and general handling properties. Dibutyl sebacate and phthalates, such as dibutyl phthalate, diethyl phthalate, dicyclohexyl phthalate, butylbenzyl phthalate, and diphenyl-2-ethylhexyl phosphate, serve widely as plasticizers in vinylidene chloride copolymers, nitrocellulose-coated regenerated cellulose film, and cellulose acetate (Castle et ah, 1988a). In PVC, di(2-ethylhexyl)... 

There are several plasticizers for PVC that may be used in propellants. Weil (19) mentions sebacates, phthalates, adipates, and glycol esters of higher fatty acids as being desirable. Dibutyl sebacate, dioctyl sebacate, and 2-ethylhexyl adipate are all good. The plasticizer has a most important effect on the physical properties of the cured propellant and the variation of these properties with temperature. Long chain, aliphatic plasticizers impart improved low temperature flexibility, and hence are preferable to aromatic plasticizers such as the phthalates. An increase in plasticizer viscosity leads to an increase in viscosity of the mixed pro-... 

The verapamil pellets contained equal parts of verapamil hydrochloride (Fermion) and lactose (Ph. Eur.) plus 4% of gelatin as a binder. They were coated using a fluidized bed technique (Aeromatic Strea 1, Aeromatic AG). The coat consisted of ethyl cellulose (Ethocel N-50), Hercules) and 20% of dibutyl sebacate (E. Merck) as a plasticizer. The calculated amount of coating in the pellets was 10%. The density of the verapamil pellets was 1.13. The in vitro dissolution pattern was determined according to the USP paddle method 50% of the drug was dissolved at 4.2 h. 

Other formulation parameters that may be used to modulate the release include the ratio (relative concentrations) of polymers in the case of incorporation of a mix of two or more polymers as primary coating material, the properties of the core material, and the amount of plasticizers used, which affects the strength of the coat. Plasticizers with low water solubility such as dibutyl sebacate, diethyl phthalate, tri-acetin, triethyl citrate, and acetylated monoglyceride result in delaying... 

Particle Size Analysis. The PSD for each unground resin in a plastisol formulation (using dibutyl sebacate as the plasticizer) was determined with the following outcome ... 

When applying the conventional food contact ratio the worst-case migration potential did not exceed the SML for any of the substances derived from plastics nor did the calculated worst-case exposure exceed the ADI/TDI or other exposure restriction value in any products. However, when the actual food contact ratio was applied the ADI/TDI or other exposure restriction value of several substances could theoretically be exceeded. The worst-case calculations assume that intimate contact is made with the entire surface of the packaging. This is not the case for the majority of snack foods that are solids or semi-solids and so the actual area of contact made will be less than the total area available for contact (e.g. crisps). The levels of those migrants (diisobutyl phthalate, dicyclohexyl phthalate, dibutyl sebacate, diphenyl 2-ethylhexyl phosphate and 2-ethyl-1-hexanol) that had the potential to exceed the assigned restrictions, assuming 100% migration, were determined in foods. Of the five substances tested for, only one, dicyclohexyl phthalate, was detected in one of the foodstuffs (tortilla corn chips), at a concentration of 0.60 ppm. 

Lanthanide enolates carrying lipophilic groups can be used as ionophores to fabricate Cl ISE membranes. Thus, electrodes with a membrane incorporating into pvc a lantanide chelate such as 61 or 62a-c, an anion excluder such as NaBPlu and a plasticizer (dioctyl sebacate, dioctyl adipate, dibutyl phthalate, dioctyl phthalate or tributyl phosphate) have... 

Liq = liquid membrane with ion-exchange solution into the porous diaphgragm PVC = plasticized poly(vinyl chloride) Epoxy = conductive epoxy resin membrane. BA = benzyl alcohol BEHP = bis(2-Ethylhexyl)phthalate DA = 1-decanol DBP = dibutyl phthalate DBS = dibutyl sebacate DNP = dinonyl phthalate DOP = dioctyl phthalate NB = nitrobenzene NPOE = 2-nitrophenyl octyl ether NT = 2-nitrotoluene or 4-nitrotoluene OA = 1-octanol. 

Using tensile testing of free films, researchers have shown that plasticizer type and concentration influence the mechanical properties of both acrylic and cellulosic polymers. ° Fig. 10 shows the influence of dibutyl sebacate concentration on the tensile properties of free ethyl cellulose films. ° As the concentration of the... 

Dibutyl sebacate is used in oral pharmaceutical formulations as a plasticizer for film coatings on tablets, beads, and granules, at concentrations of 10-30% by weight of polymer. It is also used as a plasticizer in controlled-release tablets and microcapsule preparations. 

Ethylcellulose is compatible with the following plasticizers dibutyl phthalate diethyl phthalate dibutyl sebacate triethyl citrate tributyl citrate acetylated monoglyceride acetyl tributyl citrate triacetin dimethyl phthalate benzyl benzoate butyl and glycol esters of fatty acids refined mineral oils oleic acid stearic acid ethyl alcohol stearyl alcohol castor oil corn oil and camphor. 

For spray coating, polymer solutions and dispersions should be diluted with suitable solvents. Some products need the addition of a plasticizer such as dibutyl sebacate, dibutyl phthalate, glyceryl triacetate, or polyethylene glycol. Different types of plasticizer may be mixed to optimize the polymer properties for special requirements. 

Surelease. a product of Colorcon. is produced by first melt extruding ethylcellulose with oleic acid and dibutyl sebacate (DBS) (or fractionated coconut oil) to form a molten plasticized polymeric blend. This molten blend of plasticized ethylcellulose is then introduced into an ammoniated water solution under high shear and pressure to disperse small droplets of plasticized ethylcellulose into the water phase (67). Ammonium oleate is produced in situ during this emulsification process to stabilize the colloidal ethylcellulose particles (67). Additional purified water is then added to reduce the final solids content of the pseudolatex dispersion to 25%. The Surelease coating system does not contain an ionic surfactant, and therefore does not exhibit the pH-dependent drug relea.se observed with Aquacoat ECD (66),... 

Dibutyl sebacate is a clear liquid. It is most often used for making plastics, many of which are used for packaging food. It is also used to enhance flavor in foods such as ice cream, candy, baked goods, and nonalcoholic drinks. Some consumer products, such as shaving creams, also contain dibutyl sebacate. Other names for dibutyl sebacate are decanedioic acid, dibutyl ester, sebacic acid, dibutyl ester, and dibutyl decanedioate. 

The patterns were similar with pellets containing the antihistamine phenylpropanolamine hydrochloride coated using an EC-based latex plasticized with varying amounts of dibutyl sebacate [146], The release rate was shown to be highly dependent on the osmotic pressure difference, with some contribution of the diffusion. Pores of 2 pm in diameter were visible, which is consistent with the osmotic pumping mechanism. 

Beilstein Handbook Reference) AI3-00393 Bis(n-butyl) sebacate BRN 1798308 Butyl sebacate Decanedioic acid, dibutyl ester Dl-n-butyl sebacate Dibutyl 1,8-octanedicarboxylate Dibu l decanedioate Dibutyl sebacate Oibutyi sebacinate Dibutylester kyseliny sebakove EINECS 203-672-5 FEMA No. 2373 HSDB 309 Kodaflex DBS Monoplex DBS NSC 3893 Plasthall DBS Polycizer DBS PX 404 Reomol DBS Sebacic acid, dibutyl ester Staflex DBS Uniflex DBS. Monomeric plasticizer for plastics and rubber (cellulosics, PVC food wraps, nitrite and neoprene rubbers). Used as an excipient in various pharmaceutical coaling formulations. Viscous liquid mp = -10° bp = 344.5°, bp3 = 180° d = 0.9405 insoluble in H2O, soluble in Et20, CQ4. Hall C.P. Union Camp. 

It must be emphasized, however, that quite frequently no single plasticizer can satisfy all the above requirements or produce all the desired property enhancements. It is generally necessary to blend several plasticizers and compromise some properties, particularly those that are not critical to the specific application. For example, some applications require that DOP-plasticized PVC remains flexible at low temperatures. This requires further addition of DOP to the formulation to achieve the desired flexibility, but the additional DOP would adversely affect the hardness and performance of the product at ambient temperatures. Instead, aliphatic diesters such as DOA and DBS (dibutyl sebacate), which are more effective in enhancing low-temperature flexibility than DOA, are needed to improve low-temperature performance. However, the use of these esters is accompanied by unacceptable levels of volatility and oil extraction. Consequently, in such applications a combination of phthalate and aliphatic esters is required to produce the desired product even though some compromise in product performance will occur. 

For applications where it is important to have a compound with good low-temperature resistance, aliphatic ester plasticizers are of great value. Dibutyl sebacate, dioctyl sebacate, and, more commonly, cheaper esters of similar effect derived from mixed acids produced by the petrochemical industry are used. These plasticizers give PVC products with a cold flex temperature of — 42°C. 

Chem. Descrip. Dibutyl sebacate CAS 109-43-3 EINECS/ELINCS 203-672-5 Uses Plasticizer for plastics and rubber (cellulosics, PVC food wraps, nitrile and neoprene rubbers) food pkg. adhesives, coatings, paper, rubber articles, textiles Features Monomeric... 

I PEG-16 PEG-20 PEG-32 i PEG-100 PEG-150 PEG-200 i Propylene glycol laurate plasticizer, food packaging Acetyl tributyl citrate Acetyl triethyl citrate p-t-Butylphenyl salicylate n-Butyl phthalyl-n-butyl glycolate Dibutyl sebacate Diethyl phthalate Diisooctyl phthalate Distearyl citrate Epoxidized octyl stearate Glycerin... 

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