Phenylpropanolamine hydrochloride

Common Name dl-norephedrine hydrochloride 2-amino-1-phenyl-1-propanol hydrochloride 

Trade Neme Manufacturer Country Year Introduced 

In one route as described in U.S. Patent 2,151,517, 10.7 kg of technical benzaldehyde Is vigorously agitated with a solution of 11.0 kg of sodium bisulfite in 50.0 liters of water until the formation of the addition-product is complete. Simultaneously, 8.25 kg of nitroethane is dissolved in a solution of 4.5 kg of caustic soda in 20.0 liters of water and the resultant warm solution is added with vigorous stirring to the magma of benzaldehyde sodium bisulfite. The mixture Is agitated for 30 minutes and then allowed to stand overnight. 

The aqueous portion of the mixture is now siphoned off from the supernatant layer of oily phenyinitropropanol and replaced with a fresh solution of 11.0 kg of sodium bisulfite in 50.0 liters of water. The mixture of phenyinitropropanol and bisulfite solution Is now vigorously agitated for 15 minutes in order to remove and recover small amounts of unreacted benzaldehyde, and is then again allowed to stratify. This time, the phenyinitropropanol is siphoned off and filtered to remove a small amount of resinous material. The aqueous solution of sodium bisulfite remaining behind is reacted with benzaldehyde, as described above, thus making the process continuous. 

---

This equation describes the steady-state, or zero-order, release of the dmg. When the dmg completely dissolves, its concentration within the system begins to dilute, and the release rate foUows a parabohc decline with time (102). Acutrim (ALZA Corp.), dehvering phenylpropanolamine hydrochloride [154-41 -6] for appetite suppression, is an example of an elementary osmotic pump. 

Acutrim 16 Hour Steady Control Tablets. Acuttim is an appetite suppressant diet aid available without a prescription and marketed by CIBA Consumer Pharmaceuticals. The active ingredient is phenylpropanolamine hydrochloride [154-41 -6] a sympathomimetic amine (see Antiobesity drugs). Acutrim dehvers its dosage at a precisely controlled rate for up to 16 hours. This is achieved through the OROS technology. 

Ornade Spansules Phenylpropanolamine hydrochloride, chlorpheniramine maleate SmithKline Beecham... 

Contac 12-hour capsules Phenylpropanolamine hydrochloride, chlorpheniramine maleate, atropine sulfate, scopolamine hydrobromide, hyoscyamine sulfate SmithKline Consumer Products... 

Dimetapp Extentabs Brompheniramine maleate, phenylephrine hydrochloride, phenylpropanolamine hydrochloride Robins... 

---