Monoglycerides. Acetylated

Aquatic aqueous enteric coating (cellulose acetate phthalate, distilled acetylated monoglycerides, and poloxamer 188) Film coating for tablets and capsules Repeat-dose toxicity with routine end points (90 days—diet rat), reproduction toxicity (embryo-fetal study in rat) and genotoxicity (2 in vitro and 1 in vivo studies) No adverse toxicity, reprotoxicity, or genotoxicity 31, 32... 

Cellulose acetate phthalate (CAP) dissolves at pH higher than 6 and is soluble in ketones, ethers, esters, and alcohols. Permeation of water vapor and gastric fluids is a concern but can be overcome by adding other materials such as shellac. Plasticizers that are used with CAP include diethyl phthalate, triacetin, tributyl citrate, and acetylated monoglyceride. 

Other formulation parameters that may be used to modulate the release include the ratio (relative concentrations) of polymers in the case of incorporation of a mix of two or more polymers as primary coating material, the properties of the core material, and the amount of plasticizers used, which affects the strength of the coat. Plasticizers with low water solubility such as dibutyl sebacate, diethyl phthalate, tri-acetin, triethyl citrate, and acetylated monoglyceride result in delaying... 

Acetylanisole, 450 Acetylated Distarch Adipate, 159 Acetylated Distarch Phosphate, 160 Acetylated Mono- and Diglycerides, 12 Acetylated Monoglycerides, 12 Acetylbenzene, 450... 

Several polymers were found to fit all or most of the above criteria and were used to prepare the carrier films. Many polymers have been used for this purpose, viz., ethyl cellulose, poly(y-benzyl glutamate), poly(vinyl acetate), cellulose acetate phthalate, and the copolymer of methyl vinyl ether with maleic anhydride. In addition to the base polymers, plasticizers were often needed to impart a suitable degree of flexibility. Plasticizers, which are found to be compatible with polymeric materials include, acetylated monoglycerides, esters of phthalic acid such as dibutyl tartarate, etc. An excipient was usually incorporated into the matrix of the carrier films. The excipients used were water-soluble materials, which are capable of creating channels in the polymer matrix and facilitate diffusion of the drug. PEGs of different molecular weights were used for this purpose. 

Applying zein (the principal protein of maize) in an alcoholic solution of an acetylated monoglyceride followed by drying. 

AvenaBustillos, R.D., Krochta, J.M., and Saltveit, M.E. (1997). Water vapor resistance of red delicious apples and celery sticks coated with edible caseinate-acetylated monoglyceride films. J. FoodSci. 62(2), 351-354. 

Guillard, V., Guillbert, S., Bonazzi, C., and Gontard, N. (2004a). Edible acetylated monoglyceride films Effect of film-forming technique on moisture barrier properties. J. American OilChem. Soc. 81, 1053-1058. 

Mate, J.I., and Krochta, J.M. (1997). Whey protein and acetylated monoglyceride edible coatings Effect on the rancidity process of walnuts. J. Agricult. FoodChem. 45, 2509-2513. 

Stuchell, Y.M., and Krochta, J.M. (1995). Edible coating on frozen king salmon effect of whey protein isolate and acetylated monoglycerides on moisture loss and lipid oxidation. J. FoodSci. 60, 28-31. 

Zabik, M., and Dawson, L.E. (1963). The acceptability of cooked poultry protected by an edible acetylated monoglyceride coating during fresh and frozen storage. Food Technol. 17, 87-91. 

Ethylcellulose is compatible with the following plasticizers dibutyl phthalate diethyl phthalate dibutyl sebacate triethyl citrate tributyl citrate acetylated monoglyceride acetyl tributyl citrate triacetin dimethyl phthalate benzyl benzoate butyl and glycol esters of fatty acids refined mineral oils oleic acid stearic acid ethyl alcohol stearyl alcohol castor oil corn oil and camphor. 

Cetodan. [Grindsted Pro. Grindsted Prods. Denmarii ] Acetylated monoglycerides food emulsifier, aerating agent plasticizer for chewing gum base al for resins, thermoplastics. 

Vykacet. [Croda Food Pro. Ltd.] Acetylated monoglyceride mold release agent for food industry. 

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