Analysis particle size

Physical characteristics of active API (aspect, thermal analysis, particle size distribution, optical activity, polymorphic forms, moisture content, loss on drying, microbial content, etc.)... 

Particle Size Analysis. Particle size distribution measurements of the dry resin were made using a Micromeritics Sedigraph 5000D particle size analyzer. This instrument employs a gravity settling technique and uses Stokes law to determine the particle size. The PSD was run over the size range of 0.36 to 100 micrometers. All measurements were made in dibutyl sebacate as the suspending medium. 

Image analysis Particle size distribution calculation... 

In essence, the test battery should include XRPD to characterize crystallinity of excipients, moisture analysis to confirm crystallinity and hydration state of excipients, bulk density to ensure reproducibility in the blending process, and particle size distribution to ensure consistent mixing and compaction of powder blends. Often three-point PSD limits are needed for excipients. Also, morphic forms of excipients should be clearly specified and controlled as changes may impact powder flow and compactibility of blends. XRPD, DSC, SEM, and FTIR spectroscopy techniques may often be applied to characterize and control polymorphic and hydrate composition critical to the function of the excipients. Additionally, moisture sorption studies, Raman mapping, surface area analysis, particle size analysis, and KF analysis may show whether excipients possess the desired polymorphic state and whether significant amounts of amorphous components are present. Together, these studies will ensure lotto-lot consistency in the physical properties that assure flow, compaction, minimal segregation, and compunction ability of excipients used in low-dose formulations. 

Malot and Blaisot [148] determined particle size and sphericity of low density sprays by image analysis. Particle size distribution, in the 125 to 2000 pm size range, was determined by incoherent back-light imaging and shape by morphological analysis. 

NFX 11-681 Test Methods for Particle Size Analysis-Particle Size Analysis by Gravity Sedimentation in a Liquid Medium, 360... 

From the ash samples, cross-sections were prepared and analysed by SEM. In the analysis, particle sizes and their chemical con osition were deteimined. In the analysis of chemical composition, the following elements were measured Si, Al, Fe, Ca, Mg, K, Na, Ti, P, S, Cl, (Mn), The summary results of this SEM analysis are shown in Figure 4. The con osition measured for particles was conpared with the chemical composition of ash of the feedstock straw (also indicated in Figure 4). According to the results, the most abundant substance in bottom ash was silicon, the amount of which was locally much higher than that of straw ash. The potassium content was quite equal from particle to particle. 

Properties Specific surface area, median particle diameter (see Table 3.773). Detailed chemical analysis, particle size distribution, and pore volumes and diameters available [186]. 

The practical applications of the various microscopical techniques have created opportunities for microscopists in industry and, in particular, within pharmaceutical research and development. Microscopy is used extensively, from the earliest stages of drug discovery into late development and even into manufacturing. Pharmaceutical microscopy can be conveniently divided into physico-chemical and biological applications. This chapter will consider exclusively the physico-chemical aspects of microscopy in the pharmaceutical industry. There are three broad areas in which microscopy can play an important role in the development of drugs solid-state analysis, particle size and morphology studies, and contaminant identification. This chapter presents an overview of how microscopy contributes to each of these three areas. The emphasis will be on practical examples taken from the literature and from the author s experience. 

Particle morphology Crystallographic Properties Thermal methods of analysis Particle size distribution Surface area Density... 

Rational Analysis Particle Size Distribution Critical Moisture Content Dry Strength Defiocculation Refractoriness Firing Shrinkage Vitrification. . ... 

Size Analysis, Particle Size Analysis of Construction Materials, Analytical Proceedings, Volume 21, pp. 133-134, April. 

The powder analysis basically has two segments 1) chemical analysis chemistry of the powder, powder impurities, analysis of the additives used for different processes 2) physical analysis particle size distribution, surface, morphology,... 

Analysis. See differential thermal analysis particle-size analysis ... 

SIEVE ANALYSIS (PARTICLE SIZE) TEST (ASTM D 1921)... 

As mentioned previously, real surface area (RSA) of a catalyst is one of the most important parameters when it comes to its evaluation. Part of RSA which participates in electrochemical reaction is denoted as electrochemically active surface area (ESA or EASA). However, it should be noted that ESA is usually smaller than RSA (determined by some non-electrochemical method such as gas physisorption analysis, particle size measurement etc.) due to the possibility that entire surface of the electrocatalyst is not available to electrolyte. Hence, the ratio between ESA and RSA gives catalyst utilization. The ration between ESA and geometrical cross section of an electrode gives roughness factor (Rf). There are number of different approaches to determine RSA, both electrochemical and non-electrochemical, however one should note that when electrochemical method is used it is ESA what is determined. These methods are summarized and critically overviewed by Trasatti and Petrii [13], while following section will focus on specific electrochemical methods based on voltammetry. 

TEM and EELS Analysis Particle Size and Composition of Nanoparticles... 

Particle Analysis Particle Size, Particle Shape and Structure and Surface Characterisation... 

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