Diisobutyl phthalate

Borch J, Axelstad M, Vinggaard AM, Dalgaard M (2006) Diisobutyl phthalate has comparable antiandrogenic effects to di-n-butyl phthalate in fetal rat testis. Toxicol Lett 163 183-190... 

Phthalates Dimethyl phthalate, diethyl phthalate, diisobutyl phthalate, dibutyl phthalate, dicyclohexyl phthalate, bis(2-ethylhexyl) phthalate, (2-ethylhexyl) methylphthalate... 

Meanwhile, lower monohydric alcohols were first made by the oxo process. These included n-propanol, n- and isobutanol and amyl alcohol. In PVC, only one of these assumed any importance -n-butanol - mainly in butyl benzyl phthalate. Dibutyl phthalate (DBP) was by this time considered too volatile for use in PVC in the U.S.(10). The so-called coesters - butyl octyl phthalate (BOP), butyl isodecyl phthalate and butyl cyclohexyl phthalate -have been on and off the market for many years but never achieved major success in the U.S. Dibutyl phthalate/DOP blends and BOP have probably been most successful in Japan. Diisobutyl phthalate is used in Brazil and other South American countries even today, because of its low cost. BOP is also offered in Europe, but as in the U.S., it has not been a major success. One reason could be the wide variability of composition from different suppliers. In fact, some BOP s were merely physical blends of DBP and DOP. 

When applying the conventional food contact ratio the worst-case migration potential did not exceed the SML for any of the substances derived from plastics nor did the calculated worst-case exposure exceed the ADI/TDI or other exposure restriction value in any products. However, when the actual food contact ratio was applied the ADI/TDI or other exposure restriction value of several substances could theoretically be exceeded. The worst-case calculations assume that intimate contact is made with the entire surface of the packaging. This is not the case for the majority of snack foods that are solids or semi-solids and so the actual area of contact made will be less than the total area available for contact (e.g. crisps). The levels of those migrants (diisobutyl phthalate, dicyclohexyl phthalate, dibutyl sebacate, diphenyl 2-ethylhexyl phosphate and 2-ethyl-1-hexanol) that had the potential to exceed the assigned restrictions, assuming 100% migration, were determined in foods. Of the five substances tested for, only one, dicyclohexyl phthalate, was detected in one of the foodstuffs (tortilla corn chips), at a concentration of 0.60 ppm. 

Within an investigation to develop rapid test methods to determine the migration from paper and board into food ° the migration of dibutyl phthalate, diisobutyl phthalate and DIPN from a corrugated board intended for use for... 

DIISOBUTYL PHTHALATE (84-69-5) Combustible liquid (flash point 365°F/185°C). Contact with moisture may cause decomposition. Incompatible with strong acids, strong oxidizers, nitrates. Attacks some plastics, rubber, and coatings. 

Beilstein Handbook Reference) AI3-04278 BRN 2054802 CCRIS 6193 Di-iso-butyl phthalate Di(i-butyl)phthalate DIBP Diisobutyl phthalate Diisobutylester kyseliny ftalove EINECS... 

Plasticizers (see also Chapter 1) are essentially nonvolatile solvents for PVC. At the processing temperature of about 150°C, molecular mixing occurs in a short period of time to give products of greater flexibility. Phthalates prepared from alcohols with about eight carbon atoms are by far the most important class and constitute more than 70% of plasticizers used. For economic reasons, diisooctyl phthalate (DIOP), di-2-ethylhexyl phthalate (DEHP or DOP), and the phthalate ester of the C7-C9 0x0-alcohol, often known as dialphanyl phthalate (DAP) because of the ICI trade name Alphanol-79 for the C7-C9 alcohols, are used. DIOP has somewhat less odor, whereas DAP has the greatest heat stability. Dibutyl phthalate and diisobutyl phthalate are also efficient plasticizers and continue to be used in PVC (except in thin sheets) despite their high volatility and water extractabihty. 

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