Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Synthases nitric oxide

In addition, Ji et al. docked 25 NOS inhibitors into the active site to understand the interaction mode of the inhibitors with the active site and also to understand the importance of the MIF differences in the active site for the isoform selectivity. In general, the experimental selectivities of the ligands agreed well with the derived selectivity regions. However, as the authors point out, the selectivity of some inhibitors with unusual kinetic behavior or even covalent binding to the target cannot be explained with the CPCA method. [Pg.74]

This investigation is complemented by a study by Matter and Kotsonis [59] who studied the H4Bip binding site differences between the different NOS isoforms. In addition to the available crystal structures, they also employed a homology model of human nNOS in the analysis. They also found that the grouping of the different isoforms and species in the score plot agrees with the NOS isoform classification, and they could identify a number of interactions which might be explored to enhance selectivity for nNOS. [Pg.74]


Nitric oxides Nitric oxide synthase Nitric oxide synthases Nitrided steels Nitride fibers Nitrides... [Pg.677]

Grb-2 facilitates the transduction of an extracellular stimulus to an intracellular signaling pathway, (b) The adaptor protein PSD-95 associates through one of its three PDZ domains with the N-methyl-D-aspartic acid (NMDA) receptor. Another PDZ domain associates with a PDZ domain from neuronal nitric oxide synthase (nNOS). Through its interaction with PSD-95, nNOS is localized to the NMDA receptor. Stimulation by glutamate induces an influx of calcium, which activates nNOS, resulting in the production of nitric oxide. [Pg.16]

Secretory leukocyte inhibitory protein (SLPI) Inducible nitric oxide synthase (iNOS)... [Pg.540]

Inducible (immunological) Nitric Oxide Synthase Nitric Oxide... [Pg.631]

Three isoforms of NO synthesizing enzymes ( nitric oxide synthase (NOS)) were isolated, purified, and cloned neuronal NO synthase ( neuronal nitric oxide synthase (nNOS) or isoform (I), immunological or inducible NOS ( inducible (immunological) nitric oxide synthase (iNOS) or isoform (II), and endothelial NOS ( endothelial nitric oxide synthase (eNOS) or isoform... [Pg.856]

Kleinert H, Pautz A, Linker K, Schwarz PM (2004) Regulation of the expression of inducible nitric oxide synthase. Eur J Pharmacol 500 255-266... [Pg.860]

Forstermann U (2000) Regulation of nitric oxide synthase expression and activity. In Mayer B (ed) Handbook of experimental pharmacology — nitric oxide, vol. 143. Springer, Berlin, pp 71—91... [Pg.867]

Fleming I, Busse R (2003) Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. Am J Physiol 284 R1-12... [Pg.867]

Kleinert H, Boissel J-P, Schwarz PM et al (2000) Regulation of the expression of nitric oxide synthases. In Ignarro LJ (ed) Nitric oxide, biology and pathobiology. Academic Press, San Diego, CA, pp 105-128... [Pg.867]

Endothelial Nitric Oxide Synthase (eNOS) Endothelin Converting Enzyme Endothelins Endothelium... [Pg.1491]

Collins SE, Kantak KM Neuronal nitric oxide synthase inhibition decreases cocaine self-administration behavior in rats. Psychopharmacology (Berl) 159 361-369,... [Pg.305]

Scarei S., Giovine M., Gasparini A., Damonte G., Millo E., Pozzolini M., Benatti U. Modified peptide nucleic acids are internalized in mouse macrophages RAW 264.7 and inhibit inducible nitric oxide synthase. FEB. S. Lett. 1999 451 264-268. [Pg.174]

While the fluid mosaic model of membrane stmcture has stood up well to detailed scrutiny, additional features of membrane structure and function are constantly emerging. Two structures of particular current interest, located in surface membranes, are tipid rafts and caveolae. The former are dynamic areas of the exo-plasmic leaflet of the lipid bilayer enriched in cholesterol and sphingolipids they are involved in signal transduction and possibly other processes. Caveolae may derive from lipid rafts. Many if not all of them contain the protein caveolin-1, which may be involved in their formation from rafts. Caveolae are observable by electron microscopy as flask-shaped indentations of the cell membrane. Proteins detected in caveolae include various components of the signal-transduction system (eg, the insutin receptor and some G proteins), the folate receptor, and endothetial nitric oxide synthase (eNOS). Caveolae and lipid rafts are active areas of research, and ideas concerning them and their possible roles in various diseases are rapidly evolving. [Pg.422]

Zhu Y, Jones G et al (2005) Lentivirus infection causes neuroinflammation and neuronal injury in dorsal root ganglia pathogenic effects of STAT-1 and inducible nitric oxide synthase. J Immunol 175(2) 1118-1126... [Pg.86]

Schaefer U, Schneider A, Rixen D, Neugebauer E (1998) Neutrophil adhesion to histamine stimulated cultured endothelial cells is primarily mediated via activation of phospholipase C and nitric oxide synthase isozymes. Inflamm Res 47(6) 256-264 Schaefer U, Schmitz V, Schneider A, Neugebauer E (1999) Histamine induced homologous and heterologous regulation of histamine receptor subtype mRNA expression in cultured endothelial ceUs. Shock 12(4) 309-315... [Pg.351]

Amin-Hanjani S, StagUano NE, Yamada M, Huang PL, Liao JK, Moskowitz MA. Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endotheUal nitric oxide synthase in mice. Stroke 2001 32 980-986. [Pg.115]

Han HS, Qiao Y, Karabiyikoglu M, Giffard RG, Yenari MA. Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation. J Neurosci 2002 22 3921-3928. [Pg.119]

Nitric oxide has also been implicated in PD. Thus animals with MPTP-induced Parkinsonism not only show extensive gliosis in the substantia nigra (like humans) in which the glial cells produce NO, but Liberatore and colleagues have found that in iNOS (inducible nitric oxide synthase) knock-out mice the toxicity of MPTP is halved. Since NO releases iron from ferritin and produces toxic peroxinitrate in the presence of superoxide radicals it could accelerate, even if it does not initiate, dopaminergic cell death (see Hirsch and Hunot 2000 for further details). [Pg.321]


See other pages where Synthases nitric oxide is mentioned: [Pg.1149]    [Pg.564]    [Pg.281]    [Pg.445]    [Pg.128]    [Pg.284]    [Pg.1149]    [Pg.24]    [Pg.470]    [Pg.643]    [Pg.675]    [Pg.829]    [Pg.860]    [Pg.860]    [Pg.862]    [Pg.887]    [Pg.888]    [Pg.1497]    [Pg.1498]    [Pg.161]    [Pg.463]    [Pg.75]    [Pg.100]    [Pg.222]    [Pg.282]    [Pg.465]    [Pg.495]   
See also in sourсe #XX -- [ Pg.572 , Pg.573 , Pg.574 ]

See also in sourсe #XX -- [ Pg.171 ]

See also in sourсe #XX -- [ Pg.448 ]

See also in sourсe #XX -- [ Pg.62 ]

See also in sourсe #XX -- [ Pg.253 ]

See also in sourсe #XX -- [ Pg.74 ]

See also in sourсe #XX -- [ Pg.136 , Pg.188 , Pg.189 , Pg.213 ]

See also in sourсe #XX -- [ Pg.915 ]

See also in sourсe #XX -- [ Pg.30 , Pg.32 , Pg.56 , Pg.71 , Pg.111 , Pg.114 , Pg.162 , Pg.193 , Pg.223 , Pg.256 ]

See also in sourсe #XX -- [ Pg.67 , Pg.73 , Pg.81 ]

See also in sourсe #XX -- [ Pg.2 , Pg.103 , Pg.108 , Pg.368 ]




SEARCH



Amino acids nitric oxide synthase inhibitors

Calmodulin interaction with nitric-oxide synthases

Cytokines inducible nitric-oxide synthases

ENOS expression Endothelial nitric oxide synthase

Effect on inducible nitric oxide synthase

Electron transfer nitric oxide synthase flavins

Endothelial nitric oxide synthase

Endothelial nitric oxide synthase (eNOS

Endothelial nitric oxide synthase angiogenesis, role

Endothelial nitric oxide synthase determination

Endothelial nitric oxide synthase phosphorylation

Endothelial nitric oxide synthase vascular pathology

Enzymes nitric oxide synthase

Genes inducible nitric-oxide synthases

Genes neuronal nitric-oxide synthases

Granule cells nitric oxide synthase

Heat shock protein 70/nitric oxide synthase

Hepatocytes nitric oxide synthase expression

Induce nitric oxide synthase gene

Induce nitric oxide synthase gene expression

Induced nitric oxide synthase

Inducible nitric oxide synthase

Inducible nitric oxide synthase -induced

Inducible nitric oxide synthase adenocarcinoma

Inducible nitric oxide synthase calcium independent

Inducible nitric oxide synthase expression

Inducible nitric oxide synthase expression, inhibition

Inducible nitric oxide synthase iNOS gene expression

Inducible nitric oxide synthase induction mechanism

Inducible nitric oxide synthase inflammatory processes, importance

Inducible nitric oxide synthase transcriptional activity

Inflammation nitric-oxide synthase

Inhibition inducible nitric oxide synthase

Interleukins, inducible nitric-oxide synthase

Interleukins, inducible nitric-oxide synthase inhibition

Isoenzymes Nitric oxide synthase

Manganese nitric oxide synthase

Molecular inducible nitric oxide synthase (iNOS

NADPH nitric oxide synthase binding

Neuronal Nitric Oxide Synthase in Peribronchial Microparaganglia

Neuronal nitric oxide synthase effects

Neuronal nitric oxide synthase enzyme

Neuronal nitric oxide synthase synaptic plasticity

Neurotoxicity nitric oxide synthase

Nitric Oxide Synthase Localization in the Carotid Body and Petrosal Ganglion

Nitric Oxide Synthase in Neurotoxicity Mediated by Glutamate

Nitric oxide synthase

Nitric oxide synthase

Nitric oxide synthase (NOS

Nitric oxide synthase , arginine

Nitric oxide synthase Pers

Nitric oxide synthase Subject

Nitric oxide synthase activation

Nitric oxide synthase and insulin secretion

Nitric oxide synthase calmodulin role

Nitric oxide synthase cells

Nitric oxide synthase chemical biology

Nitric oxide synthase constitutive

Nitric oxide synthase cytokine induction

Nitric oxide synthase dimeric structure

Nitric oxide synthase domains

Nitric oxide synthase electron transfer

Nitric oxide synthase expression

Nitric oxide synthase family, iNOS/eNOS/nNOS

Nitric oxide synthase functions

Nitric oxide synthase in Parkinson’s disease

Nitric oxide synthase in hepatocytes

Nitric oxide synthase inducible form

Nitric oxide synthase inflammatory response

Nitric oxide synthase inhibition

Nitric oxide synthase inhibitors

Nitric oxide synthase interleukin 1-induced expression

Nitric oxide synthase isozymes

Nitric oxide synthase knockout mouse model

Nitric oxide synthase mechanism

Nitric oxide synthase neuronal

Nitric oxide synthase oxygenase

Nitric oxide synthase physiological functions

Nitric oxide synthase properties

Nitric oxide synthase prosthetic groups

Nitric oxide synthase purification

Nitric oxide synthase reaction catalyzed

Nitric oxide synthase reactions

Nitric oxide synthase sequence homologies

Nitric oxide synthase signaling mechanism

Nitric oxide synthase tetrahydrobiopterin role

Nitric oxide synthase, inducible (iNOS

Nitric synthase

Nitric-oxide synthase conversion

Nitric-oxide synthase heme iron reduction

Nitric-oxide synthase isoforms

Nitric-oxide synthase structure

Nitric-oxide synthase substrate binding sites

Nitric-oxide synthases activation

Nitric-oxide synthases activity

Nitric-oxide synthases amino acid sequences

Nitric-oxide synthases anti-inflammatory

Nitric-oxide synthases biochemical function

Nitric-oxide synthases brain constitutive

Nitric-oxide synthases by cytokines

Nitric-oxide synthases cDNA, cloning

Nitric-oxide synthases cellular mechanisms

Nitric-oxide synthases compounds

Nitric-oxide synthases consequence

Nitric-oxide synthases cytokine effects

Nitric-oxide synthases endothelial

Nitric-oxide synthases expression regulation

Nitric-oxide synthases functions

Nitric-oxide synthases gene expression

Nitric-oxide synthases glucocorticoids

Nitric-oxide synthases heme iron

Nitric-oxide synthases inducible

Nitric-oxide synthases induction

Nitric-oxide synthases inhibition

Nitric-oxide synthases oxidation states

Nitric-oxide synthases proinflammatory

Nitric-oxide synthases signal transduction pathways

Nitric-oxide synthases tetrahydrobiopterin effects

Nitric-oxide synthases transcriptional regulation

Oxygenases nitric oxide synthases

Phosphorylation nitric-oxide synthases

Retinal nitric oxide synthase

Sepsis nitric-oxide synthase

Septic shock nitric oxide synthase inhibitors

Signaling neuronal nitric oxide synthase

Structure of Nitric Oxide Synthase

Tetrahydrobiopterin nitric oxide synthase

Tetrahydrobiopterin nitric-oxide synthase activity

The Role of Tetrahydrobiopterin in Nitric Oxide Synthase

Transcriptional regulation inducible nitric-oxide synthase gene

© 2024 chempedia.info