Genes inducible nitric-oxide synthases

Rafi, MM and Shafaie, Y, 2007. Dietary lutein modulates inducible nitric oxide synthase (iNOS) gene and protein expression in mouse macrophage cells (RAW 264.7). Mol Nutr Food Res 51, 333-340. 

Exposure to trichothecenes at levels that partially inhibit translation upregulates expression of many inflammatory and immune-related genes including macrophage, Thl and Th2 cytokines as well as chemokines, cyclooxygenase 2 and inducible nitric oxide synthase.1518 Contrastingly, suppressive effects of trichothecenes on leukocyte function are intimately linked with the induction of apoptosis as has been demonstrated in macrophages, T cells and B cells both in vivo and in vitro.19-20... 

Figure 6. Comparative gene expression ratios in ARF kidneys of MSC- and vehicle-treated animals. Data were generated by referencing each gene to p-actin as internal control. A MSC treatment cansed significant (P < 0.05) suppression (> 10 fold) of proinflammatory IL-ip, TNF a, and IFN-y (above bars actnal valnes). Anti-inflammatory lL-10 was robustly expressed in MSC-and not in vehicle treated animals. Filled bars on all panels depict gene expression ratio of 1, i.e., a value obtained when gene expression ratios between MSC- and vehicle-treated animals are "equal. B MSC treatment cansed increased gene expression of bFGF and TGF-a, whereas that of HGF was suppressed. C antiapoptotic Bcl-2 expression was robnstly indnced, whereas that of inducible nitric oxide synthase (iNOS) was snppressed in MSC- vs. vehicle-treated animals. eNOS, endothelial NOS.

Chen L, Majde JA, Krueger JM. Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes. Submitted. 

S. Brown,W.N. Rom, and M.D. Weiden. 2004. Aerosolized gamma interferon (IFN-gamma) induces expression of the genes encoding the IFN-gamma-induci-ble 10-kilodalton protein but not inducible nitric oxide synthase in the lung during tuberculosis. Infect. Immun. 72 1275-1283. 

WONG, H.R., MENENDEZ, I.Y., Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells., Biochem. Biophys. Res. Comm., 1999,262,375-380. 

Kifle Y, Monnier J, Chesrown SE, Raizada MK, Nick HS (1996) Regulation of the manganese superoxide dismutase and inducible nitric oxide synthase gene in rat neuronal and gUal cells. 

Cho S, Kim Y, Guz MO, Park EM, Chu CK, Song GY, Joh TH (2001) Repression of proinflammatory cytokine and inducible nitric oxide synthase (NOS2) gene expression in activated microglia by N-acetyl-0-methyldopamine Protein kinase A-dependent mechanism. Glia 33 324-333. 

Kim WK, Jang PG, Woo MS, Han lO, Piao HZ, Lee K, Lee H, Joh TH, Kim HS (2004) A new anti-inflammatory agent KL-1037 represses proinflammatory cytokine and inducible nitric oxide synthase (iNOS) gene expression in activated microglia. Neuro-pharmacology 47 243—252. 

Woo MS, Jung SH, Hyun JW, Kim HS (2004) Differential regulation of inducible nitric oxide synthase and cytokine gene... 

Asano, K., Chee, C., Gaston, B. etal. (1994). Constitutive and inducible nitric oxide synthase gene expression, regulation and activity in human lung epithelial cells. Proc. Natl. Acad. Sci. USA 91 (1994) 10089-10093. 

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