Infection lentivirus

Kennedy JM, Hoke A et al (2004) Peripheral neuropathy in lentivirus infection evidence of inflammation and axonal injury. AIDS 18(9) 1241-1250 Keswani SC, Pardo CA et al (2002) HIV-associated sensory neuropathies. AIDS 16(16) 2105-2117... 

Zhu Y, Jones G et al (2005) Lentivirus infection causes neuroinflammation and neuronal injury in dorsal root ganglia pathogenic effects of STAT-1 and inducible nitric oxide synthase. J Immunol 175(2) 1118-1126... 

The cultured hippocampal neurons infected with a control lentivirus or one expressing a short hairpin RNA against CPEB3 (siCPEB3- 4) for... 

Darko DF, Mitler MM, Prospero-Garcia O, Henriksen SJ. Sleep and lentivirus infection parallel observations obtained from human and animal studies. Sleep Res Soc Bull 1996 2 43-51. 

Lentivirus Attain high titre in culture Permanent infection of non-dividing cells May cause undesirable effects... 

Lentiviruses are a subclass of retroviruses expressing a complex that controls important nuclear functions in the infected cells. Lentiviruses are able to replicate in non-dividing cells, resulting in infection lasting the whole life of the host (Quinonez and Sutton, 2002). 

Oncoretroviruses are simple viruses encoding only the structural genes gag, pol, and env, whereas lentiviruses and spumaviruses have a more complex organization and encode for additional viral proteins (Figure 2). Lentiviruses encode three to six additional viral proteins that are essential for vims replication and persistence of infection. Two of the accessory proteins, tat and rev, are present in all lentiviruses and mediate transactivation of viral transcription (31,32) and nuclear export of unspliced viral RNA, respectively (33). Spumaviruses, also called foamy viruses (FV), contain, in addition to the structural proteins, three ORFs (taslbell, bel-2, and bel-3), of which taslbell has been identified as a coactivator of viral transcription (34). 

The use of vectors based on other primate lentiviruses (83,84) may also eliminate some of the concerns however, HIV-2 and simian immunodeficiency vims (SIV) are closely related to HI V-1. Therefore, vectors based on nonprimate lentiviruses like feline immunodeficiency virus (FIV), equine infectious anemia vims, and visna may be more acceptable (85-87). These viruses do not cause infection in humans due to restrictions in the envelope tropism. However, the risk associated with the introduction of nonhuman lentiviral vectors in human tissues is unknown, and the actual safety of these lentiviral vectors remains to be evaluated. 

Infection with viral vectors (e.g., adenovirus, lentivirus, retrovirus)... 

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