Nitric oxide synthase in hepatocytes

D16. De Vera, M. E Kim, Y. M., Wong, H. R Wang, Q Billiar, T. R., and Geller, D. A., Heat shock response inhibits cytokine-inducible nitric oxide synthase expression in rat hepatocytes. Hepatology 24,1238-1245 (1996). 

Kaibori, M., Sakitani, K., Oda, M., Kamiyama, Y., Masu, Y., Nishizawa, M., Ito, S., and Okumura, T. (1999). Immunosuppressant FK506 inhibits inducible nitric oxide synthase gene expression at a step of NF-k-B activation in rat hepatocytes. J. Hepatol. 30, 1138-1145. 

The role of hepatic-inducible nitric oxide synthase (iNOS) has been investigated in the rat and in the mouse. Gardner and coworkers (Gardner et al. 1998) reported that toxic doses of acetaminophen to rats induced iNOS in the centrilobular hepatocytes. The development of toxicity correlated with the expression of iNOS. Moreover, treatment of rats with the iNOS inhibitor, aminoguanidine, decreased hepatotoxicity. The role of iNOS in the progression of acetaminophen toxicity was evaluated in iNOS knockout mice. Whereas ALT levels in acetaminophen-treated iNOS knockout mice were approximately 50% of those observed in wild-type mice,... 

Sakitani K, Nishizawa M, Inoue K et al. Synergistic regulation of inducible nitric oxide synthase gene by CCAAT/enhancer-binding protein beta and nuclear fector-kappaB in hepatocytes. Genes Cells 1998 3(5) 321-330. 

K. 1998. Post-isolation inducible nitric oxide synthase gene expression due to collagenase buffer perfusion and characterization of the gene regulation in primary cultured murine hepatocytes. The Journal of Biochemistry, 124, 892-9. 

Majano, Pi., Garcfa-Monzon, C., Garcfa-Ttevijano, E.R., Corrales, F.J., Camara, J., Ortiz, P, Mato, JM., AvUa, M.A., and Moreno-Otero, R. (2001). S-adenosylmethionine modulates inducible nitric oxide synthase gene expression in rat liver and isolated hepatocytes. J. Hepatol. 35, 692-699. 

Hasselblatt, R, Rath, M., Konmenovic, V., Zatloukal, K., and Wagner, E.F. (2007). Hepatocyte survival in acute hepatitis is due to c-Jun/AP-l-dependent expression of inducible nitric oxide synthase. Proc. Natl. Acad. Sci. USA. 23, 704(43), 17105-17110. 

The dramatic effects observed when nitric oxide ( N=0) synthase is induced in cocultures of macrophages and tumor cells (Hibbs et al., 1987 Stuehr and Nathan, 1989) as well as Kupffer cells and hepatocytes (Billiar et al., 1989 ... 

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