Inducible nitric oxide synthase inhibition

Scarei S., Giovine M., Gasparini A., Damonte G., Millo E., Pozzolini M., Benatti U. Modified peptide nucleic acids are internalized in mouse macrophages RAW 264.7 and inhibit inducible nitric oxide synthase. FEB. S. Lett. 1999 451 264-268. 

Aldieri E, Atragene D, Bergandi L, et al. Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation. FEBS Lett 2003 552(2—3) 141—144. 

WONG, H.R., MENENDEZ, I.Y., Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells., Biochem. Biophys. Res. Comm., 1999,262,375-380. 

Saura M, Martinez-Daimau R, Minty A, et al. Interleukin-13 inhibits inducible nitric oxide synthase expression in human mesangial cells. Biochem J 1996 313(Pt2) 641-6. 

Kaibori, M., Sakitani, K., Oda, M., Kamiyama, Y., Masu, Y., Nishizawa, M., Ito, S., and Okumura, T. (1999). Immunosuppressant FK506 inhibits inducible nitric oxide synthase gene expression at a step of NF-k-B activation in rat hepatocytes. J. Hepatol. 30, 1138-1145. 

Jang SI, Jeong SI, Kim KJ, Yu HH, Park R, Kim HM, You YO (2003) Tanshinone IIA from Salvia miltiorrhiza inhibits inducible nitric oxide synthase expression and production of TNF-alpha, IL-lbeta and IL-6 in activated RAW 264.7 cells. Planta Med 69 1057... 

Dirsch, V. M. Kiemer, A. K. Wagner, H. Vollmar, A. M. The triterpenoid quinonemethide pristimerin inhibits induction of inducible nitric oxide synthase in murine macrophages. Eur. J. Pharm. 1997, 336, 211-217. 

A7. Aranow, J. S Zhuang, J., Wang, H Larkin, V., Smith, M., and Fink, M. P., A selective inhibition of inducible nitric oxide synthase prolongs survival in a rat model of bacterial peritonitis Comparison with two nonselective strategies. Shock 5, 16-121 (1996). 

D16. De Vera, M. E Kim, Y. M., Wong, H. R Wang, Q Billiar, T. R., and Geller, D. A., Heat shock response inhibits cytokine-inducible nitric oxide synthase expression in rat hepatocytes. Hepatology 24,1238-1245 (1996). 

Kim EJ, Hye KJ, Yong KK, et al. Suppression by a sesquiterpene lactone from Carpe-sium divaricatum of inducible nitric oxide synthase by inhibiting nuclear factor-KB activation. Biochem Pharmacol 2001 61 903-910. 

Karapiah, G. et al., Inhibition of viral replication by interferon gamma induced nitric oxide synthase, Science, 261, 1445, 1993. 

Exposure to trichothecenes at levels that partially inhibit translation upregulates expression of many inflammatory and immune-related genes including macrophage, Thl and Th2 cytokines as well as chemokines, cyclooxygenase 2 and inducible nitric oxide synthase.1518 Contrastingly, suppressive effects of trichothecenes on leukocyte function are intimately linked with the induction of apoptosis as has been demonstrated in macrophages, T cells and B cells both in vivo and in vitro.19-20... 

I nhibition of constitutive and inducible nitric oxide synthase potential selective inhibition, Anna. 

Beilman, G. J., Selective inducible nitric oxide synthase inhibition in septic shock, Crit. Care Med. 29 (2001), p. 2230-2231... 

Andrographolide, thus, has different mechanisms of anti-inflammatory activity. It can inhibit the activation of NF-kB, suppress inducible nitric oxide synthase (iNOS) expression, inhibit COX-2 expression in human fibroblast cells and also prevent oxygen radical production by human. The compound is also able to modulate T-cell activation both in vitro as well as in vivo, it is evident that it could prevent initial T-cell priming by interfering with DC maturation and antigen presentation capacity. Therefore, andrographolide may have utility as a therapeutic agent for the treatment of autoimmune diseases, such as multiple sclerosis. " ... 

Noiri et al. used AS-ODN to inhibit production of inducible nitric oxide synthase (INOS) in an attempt to prevent NO production in an ischaemic kidney. A single intravenous injection of iNOS AS-ODN attenuated acute renal failure and reduced the morphological abnormalities [129],... 

Corbett, J. A., and McDaniel, M. L. (1995). Intraislet release of interleukin 1 inhibits jS-cell function by inducing /3-cell expression of inducible nitric oxide synthase. J. Exp. Med. 181, 559-568. 

In addition to the inhibition of COX, lornoxicam shows weak inhibition of LPS-induced inducible nitric oxide synthase (iNOS IC50 65 pM) and LPS-induced interleukin-6 (IC50 54 pM), both of which could contribute to its potent anti-inflammatory and analgesic action (Berg et al., 1999). 

Berg, J., Fellier, H., Christoph, T., Grarup, J., Stimmeder, D. The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX)-1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL)-6 in vitro, Inflamm. Res. 1999, 48, 369-79. 

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