Neutrophil adhesion

Schaefer U, Schneider A, Rixen D, Neugebauer E (1998) Neutrophil adhesion to histamine stimulated cultured endothelial cells is primarily mediated via activation of phospholipase C and nitric oxide synthase isozymes. Inflamm Res 47(6) 256-264 Schaefer U, Schmitz V, Schneider A, Neugebauer E (1999) Histamine induced homologous and heterologous regulation of histamine receptor subtype mRNA expression in cultured endothelial ceUs. Shock 12(4) 309-315... 

Lewis, M. S. et al., Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion, J. Clin. Invest. 82, 2045-2055, 1988. 

Stark, J. M., E. A. van, J. J. Zimmerman, S. K. Carabell, and M. F. Tosi. 1992. Detection of enhanced neutrophil adhesion to parainfluenza-infected airway epithelial cells using a modified myeloperoxidase assay in a microtiter format. J Virol Methods 40 225 -2. 

Primary defects in neutrophils expose individuals to recurring infections. These defects may be due to a variety of causes such as neutrophil adhesion defects, defects in phagocyte function, and other causes. 

Table 7 reiterates the causes and effects of neutrophil adhesion defects. 

Brown, E., Neutrophil adhesion and the therapy of inflammation. Semin. Hematol. 34, 319-326 (1997). 

Additional antinociceptive potential of adenosine may arise from its antiinflammatory effects. These effects have been attributed to peripheral activation of A2-like receptors which, among other actions, inhibits neutrophil adhesion and prevents the secretion of proinflammatory cytokines. 

Apart from being a vasodilator, nitric oxide is also a potent inhibitor of neutrophil adhesion to the vascular endothelium. This is due to the inhibitory effect of nitric oxide on the expression of adhesion molecules on the endothelial surface. The role of nitric oxide in protecting the endothelium has been demonstrated by studies that showed that treatment with nitric oxide donors protects against ischemia- and reperfusion-mediated endothelial dysfunction. 

PF4. CXCL4. Belongs to inflammatory cytokines family, mediates the relationship between monocytes and endothelial cells, induces neutrophil adhesion and secondary granule exocytosis, and influences macrophages adhesion to endothelial cell by triggering monocyte arrest in atherosclerotic arteries... 

Immune cell adhesion molecule (ICAM-1) T cell activation, cold virus receptor neutrophil adhesion, binds LFA-1... 

Hammer, D. A. and Apte, S. M. (1992). Simulation of cell rolling and adhesion on surfaces in shear flow general results and analysis of selectin-mediated neutrophil adhesion. Biophys. J. 63, 35-57. 

Lawrence, M. B., Smith, C. W., Eskin, S. G. and Mclntire, L. V. (1990). Effect of venous shear stress on CD18-mediated neutrophil adhesion to cultured... 

Sugama Y, Hn pathi CM, Janakidevi K, Andersen TT, Fenton II,J.W., Main AB Thrond>in-iiiduc d expressioi of endothelial P-Sdeclin and intercellular adhesirai molecule 1 A niedianismfor atd)iliang neutrophil adhesion. J Cdl Biol 119 935,1992... 

W. M. Clark, B. M. Coull, D. P. Briley, E. Mainolfi, and R. Rothlein, Circulating Intercellular Adhesion Molecule-1 Levels and Neutrophil Adhesion in Stroke. Journal of Neuroimmunology. 44 (1993)123-126. 

Plusa SM, Webster N, Primrose JN. Neutrophil adhesion molecule expression and response to stimulation with bacterial wall products in humans is unaffected by parenteral nutrition. Clin Sci (Ixmd) 1996 91(3) 371. ... 

Carveth, H.J., Shaddy, R.E., Whatley, R.E., McIntyre, T.M., Preseott, S.M. and Zimmerman, G.A. (1992). Regulation of platelet-activating factor (PAF) synthesis and PAF-mediated neutrophil adhesion to endothelial cells activated by thrombin. Semin. Thromb. Hemost. 18, 126-134. 

Katayama, M., Nadel, J.A., Piedimonte, G. and McDonald, D.M. (1993). Peptidase inhibitors reverse steroid-induced suppression of neutrophil adhesion in rat tracheal blood vessels. Am. J. Physiol. 264, L316-L322. 

---