Induced nitric oxide synthase

Secretory leukocyte inhibitory protein (SLPI) Inducible nitric oxide synthase (iNOS)... 

Kleinert H, Pautz A, Linker K, Schwarz PM (2004) Regulation of the expression of inducible nitric oxide synthase. Eur J Pharmacol 500 255-266... 

Scarei S., Giovine M., Gasparini A., Damonte G., Millo E., Pozzolini M., Benatti U. Modified peptide nucleic acids are internalized in mouse macrophages RAW 264.7 and inhibit inducible nitric oxide synthase. FEB. S. Lett. 1999 451 264-268. 

Zhu Y, Jones G et al (2005) Lentivirus infection causes neuroinflammation and neuronal injury in dorsal root ganglia pathogenic effects of STAT-1 and inducible nitric oxide synthase. J Immunol 175(2) 1118-1126... 

Han HS, Qiao Y, Karabiyikoglu M, Giffard RG, Yenari MA. Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation. J Neurosci 2002 22 3921-3928. 

Nitric oxide has also been implicated in PD. Thus animals with MPTP-induced Parkinsonism not only show extensive gliosis in the substantia nigra (like humans) in which the glial cells produce NO, but Liberatore and colleagues have found that in iNOS (inducible nitric oxide synthase) knock-out mice the toxicity of MPTP is halved. Since NO releases iron from ferritin and produces toxic peroxinitrate in the presence of superoxide radicals it could accelerate, even if it does not initiate, dopaminergic cell death (see Hirsch and Hunot 2000 for further details). 

Koprowski, H., Zheng, Y.M., Heber-Katz, E., Fraser, N., Rorke, L., Fu, Z.F., Hanlon, C. and Dietzschold, B. (1993). In vivo expression of inducible nitric oxide synthase in experimentally induced ncurologjc disorders. Prt>c. Natl Acad. Sci. USA 90, 3024-3027. 

Dirsch, V. M. Kiemer, A. K. Wagner, H. Vollmar, A. M. The triterpenoid quinonemethide pristimerin inhibits induction of inducible nitric oxide synthase in murine macrophages. Eur. J. Pharm. 1997, 336, 211-217. 

A7. Aranow, J. S Zhuang, J., Wang, H Larkin, V., Smith, M., and Fink, M. P., A selective inhibition of inducible nitric oxide synthase prolongs survival in a rat model of bacterial peritonitis Comparison with two nonselective strategies. Shock 5, 16-121 (1996). 

D16. De Vera, M. E Kim, Y. M., Wong, H. R Wang, Q Billiar, T. R., and Geller, D. A., Heat shock response inhibits cytokine-inducible nitric oxide synthase expression in rat hepatocytes. Hepatology 24,1238-1245 (1996). 

Aldieri E, Atragene D, Bergandi L, et al. Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation. FEBS Lett 2003 552(2—3) 141—144. 

Lee HT, Yang SW, Kim KH, Seo EK, Mar W. Pseudoguaianolides isolated from Inula britannica var. chinenis as inhibitory constituents against inducible nitric oxide synthase. Arch Pharm Res 2002 25 151-153. 

Kim EJ, Hye KJ, Yong KK, et al. Suppression by a sesquiterpene lactone from Carpe-sium divaricatum of inducible nitric oxide synthase by inhibiting nuclear factor-KB activation. Biochem Pharmacol 2001 61 903-910. 

Rafi, MM and Shafaie, Y, 2007. Dietary lutein modulates inducible nitric oxide synthase (iNOS) gene and protein expression in mouse macrophage cells (RAW 264.7). Mol Nutr Food Res 51, 333-340. 

Gardner, C.R. et al., Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase potential role of tumor necrosis factor-alpha and interleukin-10, Toxicol. Appl. Pharmacol., 184, 27, 2002. 

Lysle, D.T. and How, T., Heroin modulates the expression of inducible nitric oxide synthase, Immunopharmacology, 46, 181, 2000. 

Lanier, R.K., Self-administration of heroin produces alterations in the expression of inducible nitric oxide synthase, Drug Alcohol Depend., 66, 225, 2002. 

MacMicking, J.D. et al., Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase, Cell, 81, 641, 1995. 

Karapiah, G. et al., Inhibition of viral replication by interferon gamma induced nitric oxide synthase, Science, 261, 1445, 1993. 

Exposure to trichothecenes at levels that partially inhibit translation upregulates expression of many inflammatory and immune-related genes including macrophage, Thl and Th2 cytokines as well as chemokines, cyclooxygenase 2 and inducible nitric oxide synthase.1518 Contrastingly, suppressive effects of trichothecenes on leukocyte function are intimately linked with the induction of apoptosis as has been demonstrated in macrophages, T cells and B cells both in vivo and in vitro.19-20... 

Kleeberger, S.R., et al., Toll-like receptor 4 mediates ozone-induced murine lung hyperpermeability via inducible nitric oxide synthase, Am. J. Physiol. Lung. Cell. Mol. Physiol. 280, 2,L326, 2001. 

Marczin N, Jilling T, Papapetropoulos A, Go C, Catravas JD 1996 Cytoskeleton-dependent activation of the inducible nitric oxide synthase in cultured aortic smooth muscle cells. Br J Pharmacol 118 1085—1094... 

Siddhanta U., Presta, A., Fan, B., Wolan, D., Rousseau, D. L., Stuehr, D.)., Domain swapping in inducible nitric-oxide synthase. Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimmer, J. Biol. Chem. 273 (1998), p. 18950-18958... 

Li, H., Raman, C. S., Glaser, C. B., Blasko, E., Young,T. A., Parkinson, J. F., Whitlow, M., Poulos. T. L., Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase, ]. Biol.Chem. 

P. D., Loftus, M., Stuehr, D. J., Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line H4B promotes assembly of enzyme subunits into an active dimmer, Proc. Natl. Acad. Sci. USA 92 (1995), p. 11771-11775... 

I nhibition of constitutive and inducible nitric oxide synthase potential selective inhibition, Anna. 

Jerome, G. M., Tjoeng, F. S., Misko, T. P., Currie, M.G., L-N6-(l-iminoethyl)lysine a selective inhibitor of inducible nitric oxide synthase,/. Med. Chem. 37 (1994),... 

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