Nitric-oxide synthases brain constitutive

Chatzipanteli K., Wada K., Busto R., and Dietrich W. D. (1999) Effects of moderate hypothermia on constitutive and inducible nitric oxide synthase activities after traumatic brain injury in the rat. J. Neurochem. 72, 2047-2052. 

Mittal, C. K., Harrell, W. B., and Mehta, C. S. (1995). Interaction of heavy metal toxicants with brain constitutive nitric oxide synthase. Mol. Cell. Biochem. in press. 

A) Nitric oxide is synthesized in vascular endothelium and the brain Nitric oxide is released from storage vesicles by acetylcholine Nitric oxide is released from exogenous molecules, eg, nitrates and nitroprusside Nitric oxide synthase is stimulated by histamine Nitric oxide synthase exists in both inducible and constitutive forms With regard to distribution of a drug from the blood into tissues (A) Blood flow to the tissue is an important determinant... 

At least three forms of nitric oxide synthase have been characterised in brain cells. Neurones produce NO mainly by Ca -dependent activation of neuronal nitric oxide synthase (nNOS or NOSl), which is constitutively expressed in these cells (Knowles and Moncada 1994). In the brain regions of rat, mouse, and bovine, the highest expression of nNOS mRNA has been observed in cerebellum (Sessa et al. 1993). In human brain, however, although the level of nNOS mRNA constitutively expressed in cerebellum was high, the highest expression was observed in putamen and caudate nucleus (Park et al. 2000). 

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