Septic shock nitric oxide synthase inhibitors

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Grover R, Zaccardelli D, Colice G, et al. An open-label dose escalation study of the nitric oxide synthase inhibitor N(G)-methyl-L-arginine hydrochloride (546C88), in patients with septic shock. Crit Care Med 1999 27(5) 913-922. 

Petros, A., Bennett, D., and Vallance, P. (1991). Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet 338, 1557-1558. 

SZABO, C., SOUTHAN, G. J., Thiemermann, C, Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase, Proc. Natl. Acad. Sci. USA 91 (1994), p. 12472-12476... 

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