Neuronal nitric oxide synthase

Weiss SW, Albers DS, ladarola MJ, Dawson TM, Dawson VL, Standaert DG (1998) NMDARl glutamate receptor subunit isoforms in neostriatal, neocortical, and hippocampal nitric oxide synthase neurons. J Neurosci 78 1725-1734. 

Bi WL, Keller-McGandy C, Standaert DG, Augood SJ (2002) Identification of nitric oxide synthase neurons for laser capture microdissection and mRNA quantification. Biotechniques 33 1274-1283... 

Grb-2 facilitates the transduction of an extracellular stimulus to an intracellular signaling pathway, (b) The adaptor protein PSD-95 associates through one of its three PDZ domains with the N-methyl-D-aspartic acid (NMDA) receptor. Another PDZ domain associates with a PDZ domain from neuronal nitric oxide synthase (nNOS). Through its interaction with PSD-95, nNOS is localized to the NMDA receptor. Stimulation by glutamate induces an influx of calcium, which activates nNOS, resulting in the production of nitric oxide. 

Three isoforms of NO synthesizing enzymes ( nitric oxide synthase (NOS)) were isolated, purified, and cloned neuronal NO synthase ( neuronal nitric oxide synthase (nNOS) or isoform (I), immunological or inducible NOS ( inducible (immunological) nitric oxide synthase (iNOS) or isoform (II), and endothelial NOS ( endothelial nitric oxide synthase (eNOS) or isoform... 

Collins SE, Kantak KM Neuronal nitric oxide synthase inhibition decreases cocaine self-administration behavior in rats. Psychopharmacology (Berl) 159 361-369,... 

Zhu Y, Jones G et al (2005) Lentivirus infection causes neuroinflammation and neuronal injury in dorsal root ganglia pathogenic effects of STAT-1 and inducible nitric oxide synthase. J Immunol 175(2) 1118-1126... 

Kulkami A., Getchell T. and Getchell M. (1994). Neuronal nitric oxide synthase is localized in extrinsic nerves regulating perireceptor processes in the chemosensory nasal mucosae of rats and humans. J Comp Neurol 345, 125-138. 

In the rat retina, ischemia upregulates expression of the neuronal nitric oxide synthase and cyclo-oxygenase-2 these effects can be effectively inhibited by lutein (Choi et al., 2006). 

Cavas, M. Navarro, J. F. (2006). Effects of selective neuronal nitric oxide synthase inhibition on sleep and wakefulness in the rat. Prog. Neuropsychopharmacol. Biol. Psychiatry 30, 56-67. 

Chen, L., Taishi, P., Duricka, D. Krueger, J. M. (2004b). Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity. Brain Res. Mol. Brain Res. 129, 179-84. 

Dzoljic, E., van Leeuwen, R., de Vries, R. Dzoljic, M. R. (1997). Vigilance and EEC power in rats effects of potent inhibitors of the neuronal nitric oxide synthase. Naunyn Schmiedebergs Arch. Pharmacol. 356, 56-61. 

Itzhak, Y., Gandia, C., Huang, P.L., Ali, S.F. Resistance of neuronal nitric oxide synthase-deficient mice to methamphetamine-induced dopaminergic neurotoxicity. J. Pharmacol. Exp. Ther. 284 1040, 1998. 

Bec, N., Gorren, A. C., Voelker, C., Mayer, B., Lange, R., Reaction of neuronal nitric-oxide synthase with oxygen at low temperature. Evidence for reductive activation of the oxy-ferrous complex by tetrahydrobiopterin, J. Biol. Chem. 273 (1998), p. 13502-13508... 

Kiff, R. J., Duffy, C., Hazelwood, R., Oplinger, J. A., Garvey, E. P., Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrulline, /. Biol. Chem. 269 (1994), p. 26677-26683... 

M. F., Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice, J. Neurochem. 

B. R., ft al., Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo, J. Neurosci. 15 (1995), p. 8419-8429... 

K., Wachter, H., Werner-Felmayer, G., Mayer, B., Identification of the 4-amino analogue of tetrahydrobiopterin as a dihydropteridine reductase inhibitor and a potent pteridine antagonist of rat neuronal nitric oxide synthase, Biochem. J. 320 (1996), p. 193-196... 

Wolff DJ, Mialkowski K, Richardson CF, Wilson SR (2001) C -fullerene monomalonate adducts selectively inactivate neuronal nitric oxide synthase by uncoupling the formation of reactive oxygen intermediates from nitric oxide production. Biochemistry 40 37 15. 

Nitric oxide is widely distributed and at least three isoenzymes of nitric oxide synthase (NOS) have been described iNOS (inducible), eNOS (endothelial) and nNOS (neuronal). The substrate for NOS is the amino acid arginine ... 

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