Nitric-oxide synthases expression regulation

Forstermann U (2000) Regulation of nitric oxide synthase expression and activity. In Mayer B (ed) Handbook of experimental pharmacology — nitric oxide, vol. 143. Springer, Berlin, pp 71—91... 

Nitric Oxide Synthase Expression and Activity Nitric Oxide Synthase Uncoupling. Inhibitory effects of quercetin on the activity or expression of endothelial NO synthases (eNOS and iNOS) has been reported but only at high concentrations (< 50 pM) [Camuesco et al., 2004 Chiesi and Schwaller 1995]. Therefore, direct changes in endothelial NO expression or activity, even when relevant to other polyphenolics, do not appear to be physiologically relevant for quercetin. However, quercetin may restore NOS expression or activity when unpaired by pathological stimuli. In fact, eNOS expression, which is up-regulated in SHR, can be corrected by chronic quercetin administration... 

Tedeschi, E. et al. Green tea inhibits human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1 alpha activation. Mol Pharmacol. 65, 111, 2004. 

Dlaska, M. and Weiss, G. 1999. Central role of transcription factor NF-IL6 for cytokine and iron-mediated regulation of murine inducible nitric oxide synthase expression. J Immunol 162 6171-6177. 

Madrigal JL, Moro MA, Lizasoain I, Lorenzo P, Castrillo A et td (2001) Inducible nitric oxide synthase expression in brain cortex after acute restraint stress is regulated by nuclear factor kappaB-mediated mechanisms. J Neurochem 76 532-538... 

Saura, M, Perez-Sala, D, Canada, R f., and Lamas, S. (1996), Role of tclrabioplerin avail-abiLty in the regulation of nitric oxide synthase expression in human mesangial cells. 

Ding Y, Vaziri ND. 2000. Nifedipine and diltiazem but not verapamil up-regulate endothelial nitric oxide synthase expression. J. Pharmacol. Exp. Ther. 292 606-9... 

Drummond GR, Cai H, Davis ME, Ramasamy S, Harrison DG. Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide. Circ Res 2000 86 347-354. 

Ambs, S., Ogunfusika, M.O., Merriam, W.G., Bennett, W.P., Billiar, T.R., Harris, C.C. (1998b). Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice. Proc. Natl. Acad. Sci. USA 95, 8823-8828. 

Chester, D.A., McCutcheon, J.A., and Reiss, C.S. (2004). Posttransciiptional Regulation of Neuronal Nitric Oxide Synthase Expression by IFN-gamma. J. Interferon. Cytokine Res. 24, 141-149. 

Kleinert H, Pautz A, Linker K, Schwarz PM (2004) Regulation of the expression of inducible nitric oxide synthase. Eur J Pharmacol 500 255-266... 

Kleinert H, Boissel J-P, Schwarz PM et al (2000) Regulation of the expression of nitric oxide synthases. In Ignarro LJ (ed) Nitric oxide, biology and pathobiology. Academic Press, San Diego, CA, pp 105-128... 

Schaefer U, Schneider A, Rixen D, Neugebauer E (1998) Neutrophil adhesion to histamine stimulated cultured endothelial cells is primarily mediated via activation of phospholipase C and nitric oxide synthase isozymes. Inflamm Res 47(6) 256-264 Schaefer U, Schmitz V, Schneider A, Neugebauer E (1999) Histamine induced homologous and heterologous regulation of histamine receptor subtype mRNA expression in cultured endothelial ceUs. Shock 12(4) 309-315... 

Li, H., Xia, N., Brausch, L, Yao, Y., and Forstermann, U., Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells, J. Pharmacol Exp. Ther., 310, 926, 2004. 

In addition we have shown that IL-1 also induces the expression of c-jun in both islets and RINm5F cells, and have obtained preliminary evidence for nuclear factor RB (NF-kB) activation (J. A. Corbett and M. L. McDaniel, unpublished observation). TTiese three transcriptional regulators alone or in combination are believed to participate in IL-1-induced expression of nitric oxide synthase by the islet j8 cell. Importantly, Nathan and co-workers have shown the presence of NF-kB response elements upstream of the mouse macrophage iNOS gene (Xie et cd., 1993). 

Sase, K., and Michel, T. 1997. Expression and regulation of endothelial nitric oxide synthase. 

---