Nitric oxide synthase properties

Griffith, O. W., Stuehr, D. J., Nitric oxide synthases properties and catalytic mechanism, Annu. Rev. Physiol. 57 (1995), p. 707-736... 

Besides cholesterol efflux from arterial wall and its role in RCT, additional properties of HDL have been proposed for its protective anti-atherogenic activities. HDL protects vascular function by a number of potential alternative mechanisms, including inhibition of LDL oxidation [8,9], platelet aggregation and coagulation [10], and endothelial monocyte adhesion [11], as well as promotion of endothelial nitric oxide synthase (eNOS) [12], and prostacyclin synthesis [13-15]. The proposed alternate protective mechanisms for HDL are attractive but many of them lack validation under in vivo conditions. 

The fluorescence properties of derivatives of oxazolo[4,5- ]pyridine has been reported by Mac et al. <2007JPP(A)188>. Martin et al. have reported the preparation of oxazolo[4,5- ]pyridine derivatives as inducible nitric oxide synthase inhibitors <2007W0045622>. 

Table 19-1 Properties of the Three Isoforms of Nitric Oxide Synthase (NOS). ...

Describe the basic properties of nitric oxide synthases (NOSs) and their varied functions in the body. What are the three different types of NOS In what ways do they differ ... 

Couture, M., Adak, S., Stuehr, D.J., Rousseau, D. L. (2001) Regulation of the properties of the heme-NO complexes in nitric-oxide synthase by hydrogen bonding to the proximal cysteine, 7. Biol. Chem. 276, 38280-38288. 

Chan, M.M.Y., Huang, H.I., and Fenton, M.R., In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with antiinflammatory properties, Biochem. Pharmacol., 55, 1955, 1998. 

Rao, C.V., Cooma, I., Simi, B., Maiming, P.T., Connor, J.R. and Reddy, B.S., Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor. Cancer Res., 62, 165, 2002. 

Cloricromsn [inn] is a benzopyran derivative, a NITRIC OXIDE SYNTHASE INHIBITOR, coronary VASODILATOR. PLATELET AGGREGATION INHIBITOR and antischaemic. It has possible ANTIINFLAMMATORY / IMMUNOSUPPRESSANT properties, and has been used to treat arterial vascular disorders where there is a... 

Ebselen (2-phenyl-1,2-benzisoselenazol-3(2//)-one), 4 and some of its derivatives mimic the action of GSH-Px.The sulfur analogue is completely inactive, an observation which highlights the importance of selenium in this redox chemistry. Ebselen has also been shown to be a nitric oxide synthase (NOS) inhibitor,to induce cytokines such as interferons, tumour necrosis factor, interleukin-2 and gratunocytemacrophage colony stimulating factor. These properties combined with Ebselen s low toxicity have led to interest in its therapeutic potential for a number of diseases.5... 

The property of NO of inhibiting mitochondrial electron transfer was first recognized in 1994 by two British research groups [14, 15] that reported the inhibition of brain and muscle cytochrome oxidase (complex IV) activity by low NO concentrations in a reversible and Oj-competitive manner. More related to the scope of this review is the NO inhibition of electron transfer at complex III, ubiquinol-cytochrome c reductase, the second NO-sensitive point in the respiratory chain, where inhibition of electron transfer between cytochromes b and c enhances mitochondrial H2O2 production [16]. Nitric oxide, produced by NO donors or by mitochondrial nitric oxide synthase (mtNOS), inhibits complex III electron transfer and increases Oy and H2O2 production in sub-mitochondrial particles and in mitochondria. Complex IV is more sensitive to NO inhibition (IC5o=O.l pM) than complex III (IC5o=O.2 pM). 

The production of NO in vascular endothelium as well as in other cell types is catalyzed by the enzyme nitric oxide synthase (NOS). Three different classes of NOS have been described through cloning techniques and other approaches (1) an endothelial form of NOS whose activity is stimulated by the binding of the Ca2+-calmodulin complex upon cellular activation of Ca2+ mobilization (2) a neural form of NOS whose activation is through a similar mechanism (i.e., intracellular Ca2+ mobilization) but whose properties are distinct from the endothelial enzyme and (3) an in-... 

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