Nitric oxide synthase family, iNOS/eNOS/nNOS

In vivo NO" is generated from the essential amino acid L-arginine by a family of enzymes called nitric oxide synthases (NOS) [1], Three isoforms have been described and cloned - endothelial NOS (eNOS), brain or neuronal NOS (nNOS), and inducible macrophage-type NOS (iNOS). All isoforms of NOS make the same products, NO and L-citrulline, by incorporating an O-atom of dioxygen into L-arginine. Only the amount of NO, the conditions under which it is made, and the location where it is synthesized differ among the three isoforms. 

Nitric oxide synthase (NOS) is a family of enzymes consisting of at least three isoforms, inducible (iNOS) found in macrophages and other cells, neuronal (nNOS) found in neurons, and endothelial (eNOS) found in endo-... 

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